C-Chloro derivatives of amino acids, the Cl being attached to a carbon not containing an amino group, are obtained by intimately contacting an amino acid containing a chain of at least 3 carbon atoms, or an N-(C1- 5 alkyl), N,N-di-(C1- 5 alkyl), N-acyl, N,N-diacyl, N-(C1-...
(UDP)-glucuronosyltransferases. Amino acid conjugation differs mechanistically from other conjugating reactions in that it is a coupled enzyme system involving any one of a number of adenosine triphosphate (ATP)-dependent acid: CoAligasesand acyl-CoA:amino acidN-acyltransferases. In relation to ...
phenylene or thienylene group and B is oxygen or a chemical bond, and salts thereof, are prepared by reacting 6-aminopenicillanic acid or a salt thereof with a carboxylic acid of Formula II wherein R1, R2, R3, A and B are as defined above or an N-acylating derivative or salt ...
d, To obtain the lactam structure, BesD was incubated with fully 15N- and 13C-labelled l-lysine, Fe, and αKG for 16 h before being quenched with 1% (v/v) formic acid in methanol to yield the [15N2,13C6]-lactam as the major product. Chloride was provided as NaCl in the enzyme...
The present invention provides an efficient method for the production of N-acyl amino alcohols via the selective acylation of the free amines of amino alcohols by reacting with an organic acid or a salt thereof with an alkyl sulfonyl chloride or an alkyl phenyl sulfonyl chloride, in an organic...
Amino acids are the building blocks of protein synthesis. They are structural elements and energy sources of cells necessary for normal cell growth, differentiation and function. Amino acid metabolism disorders have been linked with a number of pathologi
FIELD: organic chemistry, in particular production of biologically active compounds, pigments, and photographic materials.;SUBSTANCE: claimed method includes mixing of correspondent acid with aliphatic alcohol, addition of thionyl chloride and boiling of reaction mixture.;EFFECT: decreased alcohol consumption...
16. A pharmaceutical composition active against bacterial infections and comprising a pharmaceutically acceptable carrier and an antibacterially effective amount of an acylaminopenicillanic acid of the general formula I ##STR8## in which R1to R6, A and X have the meanings given above in claim 1...
Prepn. of N-acyl-N-alkylaminomethane diphosphonic acids having formula H-C(PO3H2)2-N(R1)(CO-R2), (I), (where R1 and R2 are 1-4 C alkyl) by reacting N-alkyl formamide (II) with phosphorus acid (III) and acyl chloride (IV), pref. at 40-80 degrees C. Pref. mol. ratio (I...
Despite the elegant nature of hydroamination reactions, a further four step sequence is needed to convert the obtained tertiary amines bearing an adjacent Bdan substituent to the desired α-aminoboronic acid pharmacophores and this has dramatically reduced the synthetic efficiency of the process. ...