doi:US4959461 AManssur YalpaniMagdy M. Abdel-MalikUSUS4959461 * 1989年11月14日 1990年9月25日 Domtar Inc. Processes for the preparation of amides and amines from a material having carboxyl-containing polysaccharides and products therefrom
Preparation of functionalized primary chiral amines and amides via an enantioselective three-component synthesis of propargylamines. Tetrahedron 61, 11418–11426 (2005). Article CAS Google Scholar Gommermann, N. & Knochel, P. Practical highly enantioselective synthesis of propargylamines through a ...
Modular enantioselective access to β-amino amides by Brønsted acid-catalysed multicomponent reactions Article 13 April 2023 Introduction Aliphatic amines with adjacent stereocenters are prevalent in natural products and pharmaceuticals and are often key contributors to their potent biological activity1. I...
o-NBA amides containing functional groups (biotin, fluorescent dye, and azide) provided products in near-quantitative yields (Fig.3,21–23). Finally, we applied this PANAC conjugation strategy for rapid assembly of proteolysis targeting chimeras47(PROTACs, Fig.3,24–25), which are bispecific mole...
. Amines bearing core structures important to pharmaceuticals were also efficiently converted to the desired products 3da–3ga. In all these cases, the superior reactivity of the Cu–Au system with respect to either Cu/TiO2 or Au/TiO2 was confirmed (Table ...
higher α-C–H bond strength of alkylamines than that of benzylamines and higher activation energy may result in this situation. Fig. 3: Scope of amines. Reaction conditions:1(0.20 mmol),2a(0.22 mmol), toluene (2.0 mL) under N2for 1−12 h; yield of isolated products.*Ni(...
The reaction is catalyzed by β-cyclodextrin in aqueous medium and resulted in good yields [16]. A limitation to this route is the unavailability of the starting material primary selenamides for the preparation of the selenazoles. Many synthetic strategies to primary selenoamides have been ...
That said, how do you explain why amides are significantly less basic than amines? Is it resonance? Is it inductive effects? Is it both? It seems worthwhile to devote a section to how the basicity of nitrogen is affected by its interactions with other functional groups in a pi-system. ...
A wide variety of chemical moieties react with primary amines, most notably epoxides, chloro-, bromo-, and iodoalkanes, carboxylic acid anhydrides and halides, aldehydes, α,β-unsaturated esters, nitriles, amides, and ketones. A preferred cross-linker is polyethylene glycol diglycidyl ether (PEG...
Direct Synthesis of α-Amino Amides from N-Alkyl Amines by the Copper-Catalyzed Oxidative Ugi-Type Reaction. Synlett 2012, 23, 409–412. [Google Scholar] [CrossRef] Wang, J.K.; Sun, Y.L.; Jiang, M.H.; Hu, T.Y.; Zhao, Y.J.; Li, X.; Wang, G.J.; Hao, K.; Zhen, L....