Biogenic amines (BAs) are organic bases that play several physiological roles in humans, acting as local hormones and neurotransmitters modulating smooth muscle cell contraction, vasodilatation, increased vascular permeability and mucus secretion, tachycardia, alterations of blood pressure, arrhythmias, ...
A substituted tertiary amino compound represented by general formula (I) or a pharmaceutically acceptable salt thererof. They have an aromatase inhibiting activity and are useful as a prophylactic and/or therapeutic agent for breast cancer, mastopathy, endometriosis, prostatic hypertrophy, and so forth...
In this context polyamines have many biological activities that may inhibit progression of aberrant DNA methylation acting as potential chemopreventive agents on colon carcinogenesis. However, clinical studies with this potential are still missing (Soda, 2018, Soda, 2022, Soda et al., 2013). The ...
(50 mol%) as ligand/additive in DMF at 100 °C, the desired coupling product3could be formed in 81% yield when disulfide2was used as limiting reagent and the loading of1was increased to 1.5 equiv (Fig.2a). A reversed1/2ratio gave a lower yield of 61% (see Supplementary Table1...
Four neonicotinoid nitroguanidine insecticides (imidacloprid, thiamethoxam, clothianidin, and dinotefuran) acting as nicotinic agonists account for 10鈭 15%... David,B.,Kanne,... - 《Chemical Research in Toxicology》 被引量: 75发表: 2005年 Studies on the generation of enolate anions from butane-2...
Heterocyclic aromatic amines (HAAs) form during the high-temperature cooking of meats, poultry, and fish. Some HAAs also arise during the combustion of tobacco. HAAs are multisite carcinogens in rodents, inducing cancer of the liver, gastrointestinal tra
able substances, such as ascorbate, urate or paraceta- mol. Therefore, efforts are made to decrease the applied potentials for oxidase-based detection. This problem can be resolved by using a small molecule acting as a charge transfer mediator that shuttles the electrons between the active site ...
The solutions or suspensions of the acid salts of the arylamines have been found to be capable of rapid and complete diazotization in the medium thus produced by acting on them with nitrous acid. After diazotization any desired adjustment of the pH value of the diazo solution or dilution ...
The compounds of the invention have the advantage that they may be less toxic, be more efficacious, be longer acting, have a broader range of activity, be more potent, produce fewer side effects, are more easily absorbed or have other useful pharmacological properties. ...
The predominant role of all types of organic and salt catalysts (including ionic liquids – ILs) is the stabilization of the carbamate salt, mostly by acting as a base. Catalytic enhancement depends on the combination of the amine, the base strength, the solvent, steric factors, ion pairing ...