The reaction of the α, N-diphenylnitrone with acetic anhydride has been investigated using homogeneously 18O-labelled acetic anhydride. The amount of 18O incorporated into the carbonyl group of the resulting benzamide suggests an intramolecular reaction. The rates of the reaction were measured by ...
ChemInform Abstract: REACTIONS OF ENEAMINES. XV. MECHANISM OF THE REACTION OF AMINE N-OXIDES WITH ACETIC ANHYDRIDE, THE POLONOVSKI REACTIONother reactionsDie Reaktion des N-Oxids (I) mit Essigsureanhydrid wird untersucht.doi:10.1002/chin.197632145...
The Polonovski reaction occurs when an amine oxide reacts with an acylating agent.39 The accepted mechanism involves proton removal to give a nitrogen ylide which loses acetate (using acetic anhydride) which attacks the carbon adjacent to the nitrogen atom giving an α-acetoxyamine. These intermedi...
What other reagent(s) (instead of acetic anhydride) can be used to acylate the amine, acetaminophen?Synthesis of AmideAmide is a derivative of carboxylic acid and can be made in several ways. The common ways include nucleophilic substitution reaction between amine and ...
To the resulting mixture (100 ml) was added 300 ml of acetic anhydride, and then reacted at 37°C for 3 hours. After removal of solvent by a centrifugal evaporator, the residue was dissolved with 200 m l of methanol, and followed by addition of 100 ml of 4-nitrobenzylhydroxylamine ...
Reacting an amine with an acid chloride will produce? - an ammonium ion and OH− - a salt - an amide plus HCl - an amide plus a carboxylic acid. Acid Chlorides: Examples of acid chlorides include compounds like acetyl chloride.
Their diacetate derivatives (141), however, were obtained by treatment of aminoacetamides (134; R2 = H, Me or Ph) with an α,α-dialkoxy acid or ester (139; R3 = H, Me or Ph) followed by cyclization of the resulting amide (140) with acetic anhydride. The dihydroxypyrazines ...
A solution of the product from Example 1(c) (60 mg) in methylene chloride (1 ml) was treated with acetic anhydride (290 μl) and pyridine (290 μl) and the resulting mixture was stirred at room temperature for 3.5 hours then treated with aqueous sodium bicarbonate. After a further 2 ...
B. Two-stage preparation of Me-NENA N-(2-nitroxyethyl)methylnitramine has been prepared by treating N-methyl-2-ethanolamine dinitrate with acetic anhydride,, zinc chloride, and hydrochloric acid at 400 C. The intermediate dinitrate is a crystalline salt and is best obtained by adding N-methyl...
〖合成方法〗The acetylation of 5-bromopyridine-2-amine (I) with acetic anhydride in AcOH gives the expected amide (II), which is alkylated with ethylene by means of palladium acetate, tri p-tolylphosphine and triethylamine in hot acetonitrile to yield N-(5-vinylpyridin-2-yl)acetamide (III)...