PROBLEM TO BE SOLVED: To provide a procedure for converting the amino group of a heterocyclic primary amine to a chloro group, a synthetic method of 2-chloro-5- methylthiazole and its derivatives utilizing this conversion.WAKASUGI TAKASHI
Primary amines of germanium are not usually stable and undergo deamination to lead to secondary or tertiary germylamines (equation 253). The smaller the substituents on the germanium, the more tris(germyl)amine is obtained; for example, ammonolysis of trimethylchlorogermane leads to a mixture of ...
coli cells and the previously studied tetrahydrobenzo[h][1,6] naphthyridine-6-chlorotacrine hybrid DP-128, as the reference compound [69]. The obtained results demonstrated that 12 out of the 39 compounds displayed moderate inhibitory potency against Aβ and tau aggregation, with percentages above...
N-Chloro-2,3,4,4,5,6-hexachlorocyclohexa-2,5-dienylideneamine was used as a new, mild and highly regioselective chlorinating reagent in the chlorination of phenol and o-cresol in CCl4, DMF and CH3CN. The effects of C2H5OH, C5H5N, DMF and Et3N on the regioselectivity in CCl4 have als...
7-Chloroquinolin-4-amine is an aminoquinoline that complexes ferriprotoporphyrin IX (Fe(III)PPIX) and inhibits its conversion to β-hematin (hemozoin). Definition ChEBI: 4-Amino-7-chloroquinoline is an aminoquinoline. Synthesis Reference(s) Journal of the American Chemical Society, 69, p. 704,...
(Methylenedioxy)phenylacetonitrile-->Reserpine-->Conversion catalyst-->3,4-METHYLENEDIOXYPHENETHYLAMINE HYDROCHLORIDE-->5-(2-nitroethyl)-benzo[1,3]dioxole-->3-(2H-1,3-benzodioxol-5-yl)propanamide-->Dopamine Impurity 4-->3,4-Methylenedioxy-beta-nitrostyrene-->2-Chloroethanamine-->Piperonyl aldehyde...
With slow mixing /with chloromethyloxirane/ and adequate cooling, smooth condensation to 1-chloro-3-isopropylamino-2-propanol occurs. With rapid mixing and poor cooling, a variable induction period with slow warming precedes a rapid, violent exotherm (to 350 deg C in 6 sec).Interaction /with ...
A Simple Conversion of Creatinine to Creatol via Creatinine Chloroamine 喜欢 0 阅读量: 5 作者:Toya,Yoshiaki,Tachikawa,Mariko,Ienaga,Kazuharu,Nakajima,Kiyohiko 摘要: Creatinine (2-amino-1,5-dihydro-l-methylimidazol-4 年份: 2015 收藏 引用 批量引用 报错 分享 ...
(a) Reduction of iron(II) to iron(I); (b) activation of alkyl halide by iron(I); (c) reaction of alkyl radical with nitrosoarene and subsequent reduction to give alkyl aryl amine. ArNO2, nitroarene; RX, alkyl halide; TMSCl, chlorotrimethylsilane. 16 h at 90 °C. After an acidic...
The convenient method involves the oxidative addition of aryl radical to alkenes to afford 2-arylacetophenones in the presence of tert -butyl nitrite and ascorbic acid. In addition, the efficient conversion of benzyl amines to aromatic aldehydes has also been demonstrated under aqueous mediated ...