Firstly, the weight metric selected by the authors was total body weight and not an adjusted dosing weight, which is considered more appropriate, particularly for obese patients. Secondly, there are patients with acute kidney injury as well as patients treated with continuous renal replacement ...
Endogenous creatinine clearance rate and serum creatinine which have a high correlation with serum half-life of amikacin, may be used as a guide for dosing.7 Half-life The plasma elimination half-life of amikacin is usually 2-3 hours in adults with normal renal function and is reported to ...
The dosing method of Sarubbi and Hull, which is based on corrected creatinine clearance, also has been recommended.The above dosage calculation methods should not be used in patients undergoing hemodialysis or peritoneal dialysis. In adults with renal failure undergoing hemodialysis, some clinicians reco...
Tolerance studies in normal volunteers reveal that amikacin is well tolerated locally following repeated intramuscular dosing, and when given at maximally recommended doses, no ototoxicity or nephrotoxicity has been reported. There is no evidence of drug accumulation with repeated dosing for 10 days when...
Patients with high-tone hearing loss have generally received more drug and for longer than patients without; in patients receiving long-term treatment for tuberculosis no other factors were associated with the development of ototoxicity. On multiple daily dosing, over half the patients with peak serum...
To provide information about chronic dosing of ARIKAYCE to another animal species, a 9-month inhalation toxicology study was conducted in dogs. Foamyalveolarmacrophages associated with clearance of the inhaled product were present at dose-related incidence and severity, but they were not associated with...
The population pharmacokinetic model developed in this study may be used as a basis for finding optimal amikacin dosing in a Korean patient population without a significant bias. Further studies will be needed to validate these results. 展开 ...
The primary aim of this study was to validate a higher dosing regimen for amikacin in patients with severe sep- sis and septic shock. We also evaluated the impact of body weight, and specifically of an IBW-compared with a TBW-based regimen, on the optimization of peak amika- cin ...
live. Your doctor may want to separate the dosing times by a few days or weeks to reduce the risk of an interaction, or they may want to monitor you more closely to make sure the medications are working as intended. It is important to tell your doctor about all other medications you us...
The primary aim of this study was to validate a higher dosing regimen for amikacin in patients with severe sep- sis and septic shock. We also evaluated the impact of body weight, and specifically of an IBW-compared with a TBW-based regimen, on the optimization of peak amika- cin ...