3. A phosphoramidite monomer with an MMT-protected 5′-amino group, either LNA 1040 or deoxythymidyl 11, is added to the oligonucleotide, and the amine is deprotected using trichloroethanoic acid. An LNA-acid (or DNA-acid50) monomer is coupled to the free amine using PyBOP activating ...
Finally, the group at Novartis applied the pyridine replacement in the isourea/dihydroaminooxazine series. The patent discloses head to head in vivo data with the corresponding phenyl analogs patented by Roche. The pyridine not only maintains potency in vitro but drastically improves the in vivo ...
thus providing opportunities for additional modification of the products (46–49). It was noteworthy that the reaction performed using alkenyl substituted amide-sulfoxonium ylides (50) resulted in the formation of the desired product in 82% yield with excellent selectivity. In addition, 2-aminofluoren...
state energy difference between B–H insertion, Si–H insertion, and Ge–H insertion (2.1 kcal/mol for B–H and Si–H, 1.6 kcal/mol for Si–H and Ge–H), result in excellent chemoselectivity for the Si–H vs B–H insertion and Ge–H vs Si–H insertion reactions, respectively...
G. JalsovszkyS. HollyM. HollósiJournal of Molecular StructureJalsovszky, G.; Holly, S.; Holloś i, M. Identification of Amide Bands in the FTIR Spectra of Protected Amino Acids and Dipeptides. II. Solution Spectra. J. Mol. Struct. 1995, 348, 329-332....
申请日期: 1976-06-14 公开/公告号: US4454134A 公开/公告日期: 1984-06-12 申请(专利权)人: UNION CARBIDE CORPORATION 发明人: John A. Durden Jr. 摘要: Amide oxime compounds are useful intermediates in the preparation of pesticidally active amide carbamate compounds.收藏...
Kind Code: A1 Abstract: Amido-substituted cyclohexadienes (I), in which the amido group is derived from a (cyclo)aliphatic or (hetero)aromatic carboxylic, sulfonic, carbamic or carbonic acid, are new. Amido-substituted cyclohexadienes of formula (I), in which the amido group is derived from...
1.2.3 N‐ vs. O‐protonation and Methylation and Structural Effects of N‐coordination 1.2.4 Twisted Amide Basicity and pKa Measurements 1.3 Reactivity of Bridged Lactams 1.3.1 Reactivity of the Lactam Nitrogen 1.3.1.1 Hydrolysis of the NC(O) Bond ...
Transfer of an amino group to the C-1 carboxyl group and the hydroxylation at C-6 or C-8 of spirotoamides were predicted to be catalyzed by a carboxamide synthase and P450 hydroxylases, respectively (Figure 2, path b).1 Intriguingly, under the same fermentation condition, S. griseochro-...
For instance cross linked enzyme crystals (CLEC) of the protease subtilisin have been successfully used for the hydrolysis of the terminal amide group of peptide and amino acid amides under mild reaction conditions (Scheme 9).16 Interestingly, this catalyst displayed a broad substrate tolerance, ...