Amide NH shift gradients: Quantitating peptide structure/disorder transitionsThesis (Ph. D.)--University of Washington, 1999 NMR is a powerful technique for studying the structure of polypeptides. Methods based on the Nuclear Overhouser Effect (NOE) have dominated structural studies of peptides and ...
Define secondary amide. secondary amide synonyms, secondary amide pronunciation, secondary amide translation, English dictionary definition of secondary amide. n. 1. An organic compound, such as acetamide, containing the CONH2 group. 2. The anion of ammo
Chemical Shift Anisotropy Tensors of Carbonyl, Nitrogen, and Amide Proton Nuclei in Proteins through Cross-Correlated Relaxation in NMR Spectroscopy The principal components and orientations of the chemical shift anisotropy (CSA) tensors of the carbonyl (C‘), nitrogen (N), and amide proton (HN)...
The mechanism of the reaction was studied by NMR and it was revealed that there was no transmetalation of the alkyne to the Pd catalyst. Thus, in the proposed mechanistic cycle the cationic Pd catalyst acts a Lewis acid, further activating the trifluoropyruvate toward nucleophilic attack by ...
The pro- tons in TPEQ segment of two monomers appeared at similar shift range, but their splitting patterns were dif- ferent. From the integrals of protons, it is testified that the proposed structures of TIDA I had formed with high purity. The 13C NMR spectrum of I shows 33 signals (...
(±1). The consumption of Ac-Gly-SH and formation of the ligation product Ac-Gly-Gly-OH was monitored with1H NMR (Fig.3b). As the reaction proceeds, the pH gradually decreases. We chose to maintain the pH by sequential addition of 0.2 µL aliquots of NaOD (1 M solution) ...
Solution NMR Measurement of Amide Proton Chemical Shift Anisotropy in 15 N-Enriched Proteins. Correlation with Hydrogen Bond Length § Cross-correlation between 15N1H dipolar interactions and 1HN chemical shift anisotropy (CSA) gives rise to different relaxation rates of the doublet compon... N Tj...
[h][1,3,4]thiadiazolo[2,3-b]quinazolines, benzothiadiazolotriazocine, and imidazo[2,1-b][1,3,4]thiadiazoles characterized by analytical and spectrometrical methods (IR, MS,1H and13C NMR). Compounds320–324were possessed to have the highest cytotoxicity among the eighteen compounds tested ...
The exchange rates at pH 3.1 are predicted correctly from the changes in chemical shift by assuming that helix opening is a two-state reaction. At pH values above 3.7, the nature of the helix opening reaction changes. These results indicate that at least one partially unfolded state of RNA...
(ESI positive), which show characteristic peaks in common with each other and with1(Supplementary Table4). The1H-NMR spectrum of6showed the absence of H-27, while the difference NMR spectrum of7also revealed the absence of signals corresponding to H-6, H-6′ and the C-7 acetate (H-27...