3. A phosphoramidite monomer with an MMT-protected 5′-amino group, either LNA 1040 or deoxythymidyl 11, is added to the oligonucleotide, and the amine is deprotected using trichloroethanoic acid. An LNA-acid (or DNA-acid50) monomer is coupled to the free amine using PyBOP activating ...
thus providing opportunities for additional modification of the products (46–49). It was noteworthy that the reaction performed using alkenyl substituted amide-sulfoxonium ylides (50) resulted in the formation of the desired product in 82% yield with excellent selectivity. In addition, 2-aminofluoren...
Finally, the group at Novartis applied the pyridine replacement in the isourea/dihydroaminooxazine series. The patent discloses head to head in vivo data with the corresponding phenyl analogs patented by Roche. The pyridine not only maintains potency in vitro but drastically improves the in vivo ...
The reaction tolerates a wide range of valuable functional groups, such as ether, alkene, amino, bromide, phenothiazine, pyridine, pyrrole, pyrazole, carbazole, piperidine, indole, and 1,3-benzodioxole. Furthermore, thiol could also be used as an efficient substrate react with amide-sulfoxonium ...
The α-amides of L-amino acids can be incorporated into skin treatment compositions and personal care products, such as deodorants, body sprays and antiperspirants, and used in methods for producing fragrance or attenuating or masking malodor....
申请日期: 1976-06-14 公开/公告号: US4454134A 公开/公告日期: 1984-06-12 申请(专利权)人: UNION CARBIDE CORPORATION 发明人: John A. Durden Jr. 摘要: Amide oxime compounds are useful intermediates in the preparation of pesticidally active amide carbamate compounds.收藏...
Amino PEG Acid, NH2-PEG-COOH Cat. No. PG2-AMCA-20k 20000 Da 500 mg修饰性聚乙二醇 KRAS G12C inhibitor 34 多肽定制Biotin-Pancreatic Polypeptide, human 编码 100CTPSterilin? 12mL圆底聚丙烯培养管,有刻度,无菌LSP1CS L-Serine-2-13C(Synonyms: (-)-Serine-2-13C; (S)-Serine-2-13C) 10-O-...
1.3.2 Reactivity of the Carbonyl Group 1.3.2.1 Heteroatom Nucleophiles 1.3.2.2 Organometallics 1.3.2.3 Reduction of the Carbonyl 1.3.2.4 Olefination and Epoxidation Reactions 1.3.2.5 Enolate and Conjugate Addition Chemistry 1.3.3 Polymerization Reactions ...
Transfer of an amino group to the C-1 carboxyl group and the hydroxylation at C-6 or C-8 of spirotoamides were predicted to be catalyzed by a carboxamide synthase and P450 hydroxylases, respectively (Figure 2, path b).1 Intriguingly, under the same fermentation condition, S. griseochro-...
Recent work in the Huc group has also focused on the inclusion of aliphatic units into aromatic oligoamide foldamer sequences, in particular, α-amino acids. This is a natural progression from exclusively abiotic peptidomimetics, in that the exact functional groups which mediate biomolecule recognition...