Acid-base catalyzed reaction 酸碱催化反应 Activating group 活化基团 Acyl cation 酰[基]正离子 Acyl rearrangement 酰基重排 Acylation 酰化 Acyloin condensation 偶姻缩合 Acylolysis,acyl cleavage 酰基裂解 acyloxyation 酰氧基化 Addition-elimination mechanism 加成消除机理 Additive dimerization 加成二聚 Alcoholysis...
hexamethylphosphoramide (HMPA), mechanism, triphosgeneIn this paper, hexamethylphosphoramide (HMPA) was used as the organic phosphorus coupling reagent for the synthesis of amide bond. The reaction mechanism was tracked and investigated through 31P NMR.doi:10.1080/10426500701807798...
Amide bond formation is a fundamentally important reaction in organic synthesis, and is typically mediated by one of a myriad of so-called coupling reagents. This critical review is focussed on the most recently developed coupling reagents with particular attention paid to the pros and cons of the...
The reaction is initiated by a metal-free oxidative coupling of primary alkoxides and diaminopyrimidines with Schiff base formation and subsequent annulation in the presence of large N,N-dimethylamides (e.g. N,N-dimethylpropanamide or larger). This synthetic route is in competition with a ...
(GE Healthcare). The CM5 sensor chip was used to immobilize 15,000 RU of the target protein to the sensor surface by the standard amine coupling reaction at 25 °C in PBS running buffer. Gradient concentrations of GA-amide containing 5% DMSO were injected into the channels to evaluate ...
Scheme 4.Proposed mechanism for the reaction catalyzed by HDAC8. Inhibitors for HDACs include a variety of compounds that interact with the Zn(II) center.233,273,274Hydroxamate-containing inhibitors are well known,262with suberoylanilide hydroxamic acid (SAHA) being the first HDAC inhibitor approved...
Phase Transfer of Triangular Silver Nanoprisms fromAqueous to Organic Solvent by an Amide Coupling Reaction.In this paper, we describe a procedurefor the phase transfer ofsilver nanoprisms (AgNPrs) from aqueous solution to chloroform viaan amide coupling reaction. AgNPrs are first modified with 16-...
Direct Amide Formation Between Carboxylic Acids and Amines: Mechanism and Development of Novel Catalytic Solutions Despite the amide formation reaction being a key reaction in organic chemistry, the direct amide formation reaction is both little used and little explored. Acceptance of the feasi...
Alkyne tethered benzamides undergo rhodium(III)-catalyzed intramolecular annulations to give tricyclic isoquinoline derivatives in good yields. DFT calculations suggest that the reaction mechanism involves a migratory insertion of the alkyne into the rhodium-nitrogen bond of the rhodacycle intermediate that ...
Herein, we report an integrated next generation multi-catalytic system, merging nitrile hydratase enzymes with a Cu-catalysed N-arylation reaction in a single reaction vessel, for the construction of ubiquitous amide bonds. This synergistic one-pot combination of chemo- and biocatalysis provides an ...