Leggio A, Belsito EL, Di Gioia ML, Leotta V, Romio E, Siciliano C, Liguori A (2015) Reduction of amide carbonyl group and formation of modified amino acids and dipeptides. Tetrahedron Lett 56:2062-2066Di Gioia, M.L.; Belsito, E.L.; Leggio, A.; Leotta, V.; Romio, E.; ...
Each peptide bond is planar, and each carbonyl group is an intramolecular hydrogen-bonded amide group. 每个肽键都是平面的,并且每个羰基与酰基间形成分子间的氢键。 dict.ebigear.com 3. It was found that amide-group (CONH2) drastically promoted the activity of the cyclization of the molecular chains...
1.(Elements & Compounds) any organic compound containing the functional group -CONH2 2.(Elements & Compounds) (modifier) consisting of, containing, or concerned with the group -CONH2:amide group or radical. 3.(Elements & Compounds) an inorganic compound having the general formula M(NH2)x, ...
We report structure-activity investigations in a series of tripeptide amide inhibitors of thrombin, and the development of a series of highly potent active site directed α-keto carbonyl inhibitors having the side chain of lysine at P1. Compounds of this class are unstable by virtue of reactivity...
The carbonyl group at the 2-position in (236) can be aminated directly using methylamine but the reactivity at this position can be easily enhanced by thiation (p. 617), phosphorylation (p. 618) or conversion to the imidoyl chloride. Similar activation of a 5-oxo group by thiation has...
Nucleophilic attack on the carbon atom of the carbonyl group, in reactions that lead to substitution rather than to ring opening, is discussed in this section. Pyridones and pyrones behave as cyclic amides and esters and, predictably, do not normally react with nucleophilic reagents such as HCN...
Two nonlinear dihydrazides, namely 1,2-bis(3-hydrazinocarbonylphenoxy)ethane and bis[2(3-hydrazinocarbonylphenoxy)ethyl] ether, were synthesized by the acy... CV Avadhani,PP Wadgaonkar,SP Vernekar - 《Journal of Applied Polymer Science》 被引量: 66发表: 1990年 ...
tolerated, and the corresponding axially chiral biaryl amino esters3n–3wwere generated in excellent yields (93–99%) with good-to-excellent enantioselectivities (91–98% ee). Interestingly, an additional activated keto carbonyl group in the alcohol did not influence the chemical yield, but slightly...
Firstly, the methylation of carbonyl oxygen by dimethyl sulfate occurs through transition state TS1 (25.2 kcal/mol) to form imidoesterification intermediate INT-1. Then the oxygen atom of n-butanol attacks the carbon atom of INT-1 through TS-2 (26.8 kcal/mol), yielding INT-2. INT-...
alcohol. Both primary and secondary amides could be reduced, although increasing the steric bulk of thealkyl groupdecreased the yields of the 1,4-dihydro compound dramatically, while tertiary benzamides gave either reduction of thecarbonyl groupor a very low yield of the 1,4-dihydro compound.53...