Sulfonamidocarbonylpyridin-2-carbonsureamide und ihre Verwendung als Arzneimittel Sulfonamidocarbonylpyridin-2-carboxylic acid amides and their use as medicamentsDr WeidmannDr BickelDr Guenzler-Pukall
Therefore, a review of recent developments and challenges in the formation of amide bonds from carbonyl compounds is particularly important. Herein, we have scrutinized a range of metal‐catalyzed and metal‐free approaches for the synthesis of amides from aldehydes, ketones, and oximes. In addition...
We report structure-activity investigations in a series of tripeptide amide inhibitors of thrombin, and the development of a series of highly potent active site directed α-keto carbonyl inhibitors having the side chain of lysine at P1. Compounds of this class are unstable by virtue of reactivity...
Biimidazole and bis(amide)bipyridine molybdenum carbonyl complexes as anions receptors Compounds [Mo(CO)(4)(N-N)] (N-N = 4,4'-bis((4-methylphenyl)carbamoyl)-2,2'-bipyridine, bipy', 1; or 2,2'-biimidazole, H(2)biim, 2), [MoCl(eta(3)-methallyl)... Ion LMorales DNieto S...
US5421868 * Dec 28, 1993 Jun 6, 1995 International Business Machines Corporation With carbonyl-thio- or sulfonyl-bis-amide binderUS5421868 * 1993年12月28日 1995年6月6日 International Business Machines Corporation With carbonyl-thio- or sulfonyl-bis-amide binder...
Firstly, the methylation of carbonyl oxygen by dimethyl sulfate occurs through transition state TS1 (25.2 kcal/mol) to form imidoesterification intermediate INT-1. Then the oxygen atom of n-butanol attacks the carbon atom of INT-1 through TS-2 (26.8 kcal/mol), yielding INT-2. INT-...
Carbonyl 13C NMR spectrum of basic pancreatic trypsin inhibitor: resonance assignments by selective amide hydrogen isotope labeling and detection of isotop... E. ( 1988 ) Carbonyl 13 C NMR spectrum of basic pancreatic trypsin inhibitor: Resonance assignments by selective amide hydrogen isotope labeling...
Nucleophilic attack on the carbon atom of the carbonyl group, in reactions that lead to substitution rather than to ring opening, is discussed in this section. Pyridones and pyrones behave as cyclic amides and esters and, predictably, do not normally react with nucleophilic reagents such as HCN...
of cyclic perfluoro acid anhydrides represented by formula I (Rf is perfluoroalkylene having 2-5 catenary carbon atoms or perfluorocycloalkylene having 4-7 ring atoms and X is carbonyl or sulfonyl) and amides represented by formulae II, III, IV (R and R are H or a monovalent org. group ...
Polymer Characterization The IR spectra of all polymers prepared showed char- acteristic NH, ester and amide carbonyl bands in the range of 3309, 1720, and 1651 cm - 1, respectively. Ele- mental analyses also supported the formation of ex- pected polymers. The microstructure of polymers was...