The compounds are useful as selective LTB4 receptor antagonists in the treatment of conditions or syndromes in mammals which are responsive to LTB4 receptor antagonism.MORRISSEY, MICHAEL M.SUH, HONGSUK
SUBSTITUTED AMIDINO COMPOUNDS, THEIR MANUFACTURE AND PHARMACEUTICAL COMPNS. CONTG. THE SAID COMPDS.PCT No. PCT/US93/10876 Sec. 371 Date Jul. 25, 1995 Sec. 102(e) Date Jul. 25, 1995 PCT Filed Nov. 12, 1993 PCT Pub. No. WO94/11341 PCT Pub. Date May 26, 1994 ...
phosphoramidatesBridge to the right angle: A methylene bridge between the C3′ and N5′ atoms restricts the γ dihedral angle of an oligonucleotide P3′→N5′ phosphoramidate within the +sc orientation (see scheme), which improves duplex‐forming ability and accelerates hydrolytic cleavage.Satoshi...
The reaction of amidinothioureas (II) with aldehydes or acetone and with methyl chloroacetate were found to form 6-amino-4-mercapto-2-substituted 1, 2-dihydro-1, 3, 5-triazines (III) and 2-guanidylidene-4-thiazolidones (V), respectively.doi:10.1002/chin.197823240...
AMIDINO DERIVATIVES, PHARMACEUTICAL COMPNS. CONTG. THEM AND PROCESS TO PREPARE THEMPCT No. PCT/GB92/02387 Sec. 371 Date Jun. 22, 1994 Sec. 102(e) Date Jun. 22, 1994 PCT Filed Dec. 23, 1992 PCT Pub. No. WO93/13055 PCT Pub. Date Jul. 8, 1993 ...
AMIDINOHYDRAZONE, ALKOXYGUANIDINE AND AMINOGUANIDINE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIOThe present invention is directed to aminoguanidine and alkoxyguanidine compounds, including compounds of Formula (I) wherein X is O or NR?19 and A1, A2, R7-R10, R18,...
Preparation process for aminated derivatives of alkyloxyfuranone, compounds originating form this process and use of these compounds.The invention relates to a novel process for preparing compounds of the formula (IV) or (I):from the racemic alkoxyfuranone of the formula (II):R1 and R2 being...
FIELD OF THE INVENTION The present invention relates to piperidinyl and N-amidino-piperidinyl derivatives of formula (I) having an inhibitory effect on factor Xa. The present invention encompasses compounds of formula (I) for use in the preparation of compounds, e.g. preparations for inhibiting ...
PROCESS FOR PREPARING NOVEL AMIDINO DERIVATIVES AND PHARMACEUTICAL COMPNS. CONTG. THEM AND PROCESS FOR PREPARING PHARMACEUTICAL COMPNS. CONTG. KNOWN AMIDINO DERIVATIVES WITH NITRIC OXIDE SYNTHASE INHIBITING ACTIVITYFIELD OF THE INVENTION The present invention relates to novel amidine derivatives of formula...
amino gp. the MA units comprising >0.2% of the mixt., or by aminating the mixt. of (I) and the copolymer either in the molten state or as a finished product contg. 0.2% MA units using polyamine with >1 prim. amino gp.LAMBERT BNICCO A...