Below is an example plate used to detect the DNA damage when a genotoxic material is exposed to the SOS ChromoTest Bacteria. Potential applications of the SOS-ChromoTest that take advantage of the genetically engineered strain of E. coli, including testing of effluents for possible mutagenic or ...
The Ames Salmonella/microsome assay is a widely used short term test for mutagenicity. The addition of a mutagenic chemical agent to a plate of cultured cells results in the growth of mutant colonies; the number of such colonies is an indicator of the mutagenic potency of the agent. We ...
The bacterial reverse mutation assay (also known as Ames assay) is widely used in genotoxicity screening of test articles for their mutagenic potential (particularly, point mutation-inducing activity) and is regulated in the OECD genetic toxicology test guidelines. In this assay, amino-acid requiring...
ChemInform Abstract: Benzofuran Dioxetanes, a New Class of Mutagenic Agents: Synthesis by Photooxygenation of Benzofuran Derivatives. ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a Chem... W Adam...
In the light of finding a good candidate for HRT and given that natural products are promising sources of novel potentially therapeutic agents, another purpose of the present study was to investigate the mutagenic activities of C. pallida by the Ames test, in order to contribute to a toxicologic...
In the antimutagenicity studies, DRDE-07 and DRDE-35 showed promising antimutagenic activity against SM in the absence of S9, in comparison to amifostine. DRDE-07 and DRDE-35 are promising protective agents against SM-induced mutagenicity. 展开 关键词: Sulfur mustard Mutagenicity Amifostine DR...
Section > Chapter Hakura, A.; Mochida, H.; Tsutsui, Y.; Yamatsu, K. Mutation Research 347(1): 37-43 1995 ISSN/ISBN:0027-5107 7596366 10.1016/0165-7992(95)90031-4 009066180 Article emailed within 0-6 h Payments are secure & encrypted ...
Section > Chapter Hakura, A.; Mochida, H.; Tsutsui, Y.; Yamatsu, K. Mutation Research. Section on Environmental Mutagenesis and Related Subjects 334(3): 391 1995 ISSN/ISBN:0165-1161 10.1016/0165-1161(95)90089-6 062470151 Article/Abstract emailed within 0-6 h ...
Quantitative assessment of the dose-response of alkylating agents in DNA repair proficient and deficient ames tester strainsAmes testdose–response relationshipDNA repairPROASTMutagenic and clastogenic effects of some DNA damaging agents such as methyl methanesulfonate (MMS) and ethyl methanesulfonate (EMS)...
Positive results in the Ames test correlate well with carcinogenic potential in rodents. This correlation is not perfect because mutations are only one of many stages in tumour development. Also, situations can be envisaged where the mutagenic response may be specific to the bacteria or the test ...