Mexico is American’s largest international destination, where the airline operates more than 500 weekly flights to 27 cities: Acapulco, Aguascalientes, Cancún, Chihuahua, Mexico City, Cozumel, Culiacan, Durango, Guadalajara, Hermosillo, Huatulco, La Paz, León, Loreto, Mazatlán, Mérida, Monterrey...