德国哥廷根,2018年3月14日——作为国际领先的生物制药行业供应商,Sartorius Stedim Biotech (SSB) 于今日宣布推出ambr® 250高通量 (ht) 灌注系统。这是一款全新的自动化并行生物反应器系统,专为加快细胞培养灌注工艺开发而设计,目的是优化治疗性抗体的生产。该系统在美国旧金山举办的2018年BPI西部会议 (2018年3月1...
Shake flasks and the ambr250 HT were used to compare centrifugation and in situ gravity settling protocols. The centrifugation protocol achieved a peak VCD >50 million cells/mL and is well-suited to media formulation and feeding strategy comparisons. The in situ gravity settling protocol achieved ...
Ambr® 250 Modular 是一种易于使用的创新型台式生物反应器系统,应用集成式100-250mL工作体积的一次性微型生物反应器,每个反应器罐体集成了5个补料管,最多可同时运行8个罐体。可应用于工艺优化,工艺表征,以及工艺缩小模型,提高工艺开发效率并加快获得工艺深入理解。 7月25-27日,赛多利斯上海应用中心将举办为期3天的...
The automated ambr250® stirred-tank bioreactor platform provides an effective platform for high-throughput process development. However, the original dual pitched-blade 20 mm impeller and baffles proved sub-optimal for cell therapy candidates that require suspension of microcarriers (e.g. for the ...
ambr® 250高通量 (ht) 灌注培养系统,是一款全新的自动化并行生物反应器系统,专为加快细胞培养灌注工艺开发而设计,用于优化治疗性抗体的生产。 想直观的了解这一革命性产品的前世今生? 想直接看到它的创新功能和优势? 观看视频, ambr® 产品经理Barney Zoro博士将为你揭示这些创新功能和优势,你将收获良多。
Use of the ambr 250 in combination with high-throughput design and analysis tools for rapid , scalable USP development There have been many recent advances in high throughput (HT) technologies for upstream development, enabling processes to be developed in a fraction of the time compared with conv...
250 HT. More recently, as continuous processing for biologics has gained traction, driven by novel technology and economic pressure to significantly improve monoclonal antibody (mAb) production over the standard fed-batch process, more efficient, cost effective, and environmentally sustainable mAb ...
High-throughput (HT) fermentor systems, such as the Ambr 250 HT, can significantly accelerate process development timelines of pDNA upstream processes compared to traditional bench-scale glass fermentors or small-scale steam-in-place (SIP) fermentors. However, such scale-down models must be ...
The ambr(R)250 (24way) parallel bioreactor system (which enables multiple, simultaneous fermentations to be carried out under fully automated control) has the confirmed reproducibility and scalability that is required, and should be used in combination with HT analytics tools (e.g. the Cedex Bio...
In this review, the authors describe a systematic approach toward SDM development in one of the most widely adopted MBRs, the ambr 15 and 250?mL (Sartorius Stedim Biotech) systems. Recent efforts have shown promise in qualifying ambr systems as SDMs to support more efficient, robust and safe...