Methods: Eligible patients (pts) with advanced or metastatic solid tumors were assigned to: Arm A (tinengotinib 12 mg QD), Arm B (tinengotinib 8/10/12 mg QD in combination with 100 mg/m2 Abraxane, HER2- BC); Arm C PK...
Eligible pts were age $70 years (amended to $65). Pts had CrCl $ 40 mL/min, bilirubin # 1.5 x ULN, and no other life-limiting intercurrent illness. Pts were stratified based on Rai stage and +/- del17p13.1 by FISH, and randomized 1:1 to ...