This CBF increase led to improved performance on spatial and working memory tasks in APP/PS1 mice, even at late stages of disease progression38,39. Obesity is also a driver of chronic, systemic inflammation. For example, studies in both humans40 and mouse models41,42 have shown that obesity...
Toward defining the preclinical stages of Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7(3):280–92. Article PubMed PubMed Central Google Scholar Albert MS, ...
Stage 4 refers to symptomatic dementia with demonstrable cognitive and functional impairment and was specifically not covered in the guidance. The efficacy outcomes for stages 1 and 2 are summarized in the report and commented extensively on elsewhere, most notably discussed at the Alzheimer's Disease...
One of the hardest moments for not only the person with dementia, their caretaker, and their family, is deciding the appropriate time to relocate to an assisted living facility or a skilled nursing home. Like the variety of the disease symptoms and durations, the question of when to accept ...
Illumina HiSeq 2000 sequencing followed by individual quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) assays was used to test the difference in levels of serum miRNAs between 50 AD patients and 50 controls in the screening stages. The detected serum miRNAs then were validated ...
This is a trend analysis aimed at understanding the characteristics and trajectory of change over time in AD drug development, as well as trends across phases and mechanistic categories of AD candidate therapies. Two-sample t tests were used to compare trial durations and sample sizes in Phase 2...
The purpose of this study was to comprehensively examine the distinct features of OSA (e.g., number of OSA-related events per hour or time spent during sleep with blood oxyhemoglobin levels in hypoxemia) across the whole night and broken down by distinct sleep stages (NREM versus REM), since...
Gamma sensory stimulation resulted in a reduction in sleep fragmentation, as quantified by a decrease in nighttime active durations of the 6-month treatment period. In participants who received sham stimulation, increases in sleep fragmentation were measured over the same time period. LP04: APPLYING ...
Fixation durations were also shorter in aMCI patients compared to HCs. Also, AD patients were more fixated on distractors than HCs. DISCUSSION Our findings revealed that visual search is impaired in the early stages of AD and even aMCI, highlighting the importance of addressing visual processes ...
Early Diagnosis Focus: The framework is specifically designed to facilitate the early and accurate diagnosis of Alzheimer’s disease, which is important for timely medical intervention. Objective: To provide a reliable tool for detecting Alzheimer’s at earlier stages, potentially improving patient outcom...