In its earliest clinical phase, Alzheimer's disease characteristically produces a remarkably pure impairment of memory. Mounting evidence suggests that this syndrome begins with subtle alterations of hippocampal synaptic efficacy prior to frank neuronal degeneration, and that the synaptic dysfunction is ...
Mounting evidence suggests that this syndrome begins with subtle alterations of hippocampal synaptic efficacy prior to frank neuronal degeneration, and that the synaptic dysfunction is caused by diffusible oligomeric assemblies of the amyloid beta protein.关键词: Alzheimer's Disease Is a Synaptic Failure,...
De Strooper, B. & Karran, E. The cellular phase of Alzheimer’s disease. Cell 164, 603–615 (2016). Article PubMed Google Scholar Selkoe, D. J. Alzheimer’s disease is a synaptic failure. Science 298, 789–791 (2002). Article ADS CAS PubMed Google Scholar Palop, J. J. & Muc...
Alzheimer’s disease (AD) is characterized by a progressive loss of memory that cannot be efficiently managed by currently available AD therapeutics. So far, most treatments for AD that have the potential to improve memory target neural circuits to prote
Therapies targeting late events in Alzheimer’s disease (AD), including aggregation of amyloid beta (Aβ) and hyperphosphorylated tau, have largel
Is synaptic loss a unique hallmark of Alzheimer's disease? Biochem Pharmacol 2014;88:517Y28Scheff SW, Neltner JH, Nelson PT (2014) Is synaptic loss a unique hallmark of Alzheimer’s disease? Biochem Pharmacol 88(4):517–528. : 10.1016/j.bcp.2013.12.028 Central...
The accumulation of amyloid-β protein (Aβ) in brain is linked to the early pathogenesis of Alzheimer’s disease (AD). We previously reported that neuron-derived exosomes promote Aβ clearance in the brains of amyloid precursor protein transgenic mice and that exosome production is modulated by...
D.J. Selkoe Alzheimer’s disease is a synaptic failure Science, 298 (2002), pp. 789-791 View in ScopusGoogle Scholar 121 J.J. Palop, L. Mucke Network abnormalities and interneuron dysfunction in Alzheimer disease Nat Rev Neurosci, 17 (2016), pp. 777-792 CrossrefView in ScopusGoogle Scho...
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Why Alzheimer's is a Disease of Memory: Synaptic Targeting by Pathogenic Aβ Oligomers (ADDLs) In: Selkoe DJ, Triller A, Christen Y, editors. ... WL Klein,FD Felice,PN Lacor,... - Synaptic Plasticity & the Mechanism of Alzheimers Disease 被引量: 0发表: 2008年 Synaptic targeting by ...