NINCDS-ADRDAdementiaKeywords: geriatric psychiatry; Alzheimer's Disease; ICD-10; DSM-IV; NINCDS-ADRDA; dementiaJohn R. M. CopelandDepartment of Addictive Behaviour and Psychological Medicine, St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UKMohammed T. Abou-Saleh...
Although the pathogenesis of Alzheimer’s disease (AD) is unclear, neuroinflammation appears to play a role in its development. Psoriasis is a chronic inflammatory skin disease that has recently been found to genetically overlap with AD. We aimed to inve
Alzheimer’s disease (AD) is the most common cause of dementia, making up 60–80% of cases, with a large and increasing burden on patients, caregivers, and society1. AD is characterized by brain atrophy and accumulation of beta-amyloid plaques and tau tangles seen on brain pathology after ...
We evaluated the effect of Alzheimer's disease (AD) susceptibility loci on endophenotypes closely related with AD pathology in patients with mild cognitive impairment (MCI). Methods We selected 1730 MCI patients from four independent data sets. Weighted polygenic risk scores (PGS) were constructed of...
Dyslipidemia was defined as (i) the presence of at least one claim per year under ICD-10 code E78 for the prescription of a lipid-lowering agent, or (ii) total cholesterol ≥ 240 mg/dL. Chronic kidney disease (CKD) was defined as a glomerular filtration rate < 60 mL/min/...
Do Periodontal Pathogens or Associated Virulence Factors Have a Deleterious Effect on the Blood-Brain Barrier, Contributing to Alzheimer’s Disease? Abstract:The central nervous system (CNS) is protected by a highly selective barrier, the blood-brain barrier (BBB), that regulates the exchange and ...
Strydom A, Coppus A, Blesa R et al (2018) Alzheimer's disease in Down syndrome: An Zeitschrift für Gerontologie und Geriatrie 7 overlooked population for prevention trials. Alzheimers Dement 13(4):703–713 8. Loosli S, Schmidt L, Nübling G et al (2021) Kognition bei Down-Syndrom: ...
Incidence rate ratios by overall medication category in the 10-year study period and in time intervals. Incidence rate ratios (IRRs) for young onset Alzheimer’s disease are plotted by overall medication categories in the 10-year retrospective study period and in three time-intervals prior to dia...
The advancement of diagnostic and therapeutic interventions in early Alzheimer’s disease (AD) has demanded the economic evaluation of such interventi
Alzheimer’s dementia (AD) is a neurodegenerative disease that is disproportionately prevalent in racially marginalized individuals. However, due to research underrepresentation, the spectrum of AD-associated comorbidities that increase AD risk or sugges