These results suggest that the widespread belief of the association between apraxia and cortical dementias is not exactly correct. The significant difference between both of the dementia groups and the MCI patients suggests that the absence of apraxia can be an indicator for MCI diagnosis....
The genotype association with relapse was nonsignificant among younger smokers. An increased understanding of the underlying pathophysiological mechanisms of this association could facilitate the development of targeted therapies for smokers with increased risk for cognitive decline. 展开 ...
Two genome-wide association studies together report three new susceptibility loci for late-onset Alzheimer's disease. CLU, PICALM and CR1 may be involved in amyloid- clearance from the brain.doi:10.1038/ng1009-1047Michael A van EsLeonard H van den Berg...
A Bonferroni-corrected threshold of p < 8.33 ? 10-3 was considered significant, and p values between 8.33 ? 10-3 and 0.05 were considered to be suggestive of an association.Ma, Ya-HuiYang, Yu-XiangShen, Xue-NingChen, Shi-DongTan, LanDong, QiangYu, Jin-Tai...
Our results showed that there is no association between the –889 C/T transition on the interleukin-1α gene and late-onset AD in the Turkish population.Copyright © 2009 S. Karger AG, Baseldoi:10.1159/000193627Dursun, ErdinçGezen-Ak, DuyguErtan...
We examined whether smokers who carry at least one epsilon 4 allele (n = 252) have more difficulty quitting smoking compared with noncarriers (n = 665), and whether age moderated this association. The genotype by age interaction was significant for 7-day point-prevalence abstinence rates (P ...
Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer’s disease. Neurology 1993, 43, 1467–1472. [Google Scholar] [CrossRef] [PubMed] Harold, D.; Abraham, R.; Hollingworth, P.; Sims, R.; Gerrish, A.; Hamshere, M.L.; Pahwa, J.S.; ...
Association between acetylcholinesterase and beta-amyloid peptide in Alzheimer’s cerebrospinal fluid. Chem. Biol. Interact. 2008, 175, 209–215. [Google Scholar] [CrossRef] [PubMed] Sridhar, G.R.; Nirmala, G.; Apparao, A.; Madhavi, A.S.; Sreelatha, S.; Rani, J.S.; Vijayalakshmi...
The lack of strong association between brain beta-amyloid deposition and cognitive impairment has been a challenge for the Alzheimer's disease (AD) field. Although beta-amyloid is necessary for the pathologic diagnosis of AD, it is not sufficient to make the pathologic diagnosis or cause dementia...
The ADNI is funded by the National Institute on Aging and the National Institute of Biomedical Imaging and Bioengineering and through generous contributions from the following: AbbVie; Alzheimer’s Association; Alzheimer’s Drug Discovery Foundation; Araclon Biotech; BioClinica, Inc.; Biogen; Bristol-...