and the accumulation of this protein does not have any effect on the cognitive status or functional capacity ofthe brain.[0005] In recent years it is becoming more widely accepted that the pathogenic basis of Alzheimer’s disease is theaberrant re-entry of different...
Background: Molecular and/or structural lesions in hippocampal neurons in Alzheimer's disease (AD) are thought to impair learning and memory (L & M), which depends on plasticity of dendritic spines. In AD, intracellular amyloid (icA尾) could damage synapses early in pathology, while Tau is ...
INTRODUCTION: Subcortical hyperintensities (SHs) are radiological entities commonly observed on magnetic resonance imaging (MRI) of patients with Alzheimer's disease (AD) and normal elderly controls. Although the presence of SH is believed to indicate some form of subcortical vasculopathy, pathological he...
Background: Cognitive studies have established that the hippocampal formation is the first brain structure targeted by Alzheimer's disease (AD). A complex structure, the hippocampal formation is made up of separate but interconnected subregions. functionally organized as a circuit. Methods: Here, we ...