and ii) culturing the macrophages in an alveolar macrophage-inducing medium comprising granulocyte macrophage colony stimulating factor (GM-CSF), and optionally macrophage colony stimulating factor (M-CSF), under suitable conditions and for a sufficient period of time to yield alveolar-like macrophages....
Both T cells and lung macrophages are involved in the control of lung tuberculosis infection. Here the authors examine the dependence of the lung macrophage response upon the presence of T cells and show that CD4 and CD8 T cells promote the elimination of M.Tb in alveolar macrophages but have...
As the particle burden in the lung increases, alveolar macrophages and epithelial cells are activated, resulting in the release of inflammatory mediators, ROS, enzymes (like collagenase, elastase, and proteases), cytokines [likeTNFα, macrophage inflammatory protein (MIP-1), and TGFs] that ...
E. Beyond stem cells: self-renewal of differentiated macrophages. Science 342, 1242974 (2013). Article PubMed CAS Google Scholar Amit, I., Winter, D. R. & Jung, S. The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis. ...
can divide and can either phagocytize particulate material that crosses the alveolar walls or move into the alveolar compartment to become alveolar macrophages. Another macrophage-like cell in the interstitium is the dendritic cell. Dendritic cells have little, if any, phagocytic potential but are sp...
Type 2 alveolar epithelial (AT2) cells of the lung are fundamental in regulating alveolar inflammation in response to injury. Impaired mitochondrial long-chain fatty acid β-oxidation (mtLCFAO) in AT2 cells is assumed to aggravate alveolar inflammation in acute lung injury (ALI), yet the importanc...
which binds to another receptor on the surface of microbial cells, the pathogen-associated molecular receptor. This interaction facilitates the phagocytosis of the pathogen and the secretion of pro-inflammatory cytokines to enhance the local immune response. Within the alveolar macrophage, engulfed microbe...
12-o-Tetradecanoyl-phorbol-13-acetate-differentiated U937 cells express a macrophage-like profile of neutral proteinases. High levels of secreted collagena... cells for production of collagenase, since human alveolar macrophages release fibroblast-like collagenase, an enzyme that is distinct from neutroph...
MH-S Cells | MH-S Mouse Alveolar Macrophage Culture Medium information, including chemical properties, structure, melting point, boiling point, density, formula, molecular weight, uses, prices, suppliers, SDS and more, available at Chemicalbook.
This pattern of macrophage activation resulted in high expression of MHC class II antigens by A/J cells, while B10.A macrophages expressed elevated levels of CD40. Unexpectedly, our results demonstrated that susceptibility to a fungal pathogen can be associated with an efficient innate immunity, ...