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Alu RNA accumulation due to DICER1 deficiency in the retinal pigmented epithelium (RPE) is implicated in geographic atrophy (GA), an advanced form of age-related macular degeneration that causes blindness in millions of individuals. The mechanism of Alu RNA-induced cytotoxicity is unknown. Here we...
3′-end sequence that can form stem-loop is highlighted in blue. b Alu 3′-end stem-loop structure from the sequence highlighted in blue in the section (A) Full size image Reconstructed stem-loop conservation profiles revealed presence of conserved positions along the entire transposon length ...
Declaration of competing interest Acknowledgments Appendix A. Supplementary data Data availability ReferencesShow full outline Cited by (3) Figures (6) Tables (3) Table 1 Table 2 Table 3 Extras (1) Supporting information for this article.Science...
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