Presents alternative methods in testing animals within the laboratory of Notox Safety & Environmental Research. Potential of skin corrosion test; Application of test substance and the cell viability measurement; Availability of local lymph node assay.BuskensCarinvanHuygevoortTonSpeciality Chemicals...
Building a case to ban all animal testing Occasionally, across our wider product portfolio, some of the ingredients we use have to be tested by our suppliers to comply with legal and regulatory requirements in some markets; and some governments still test certain products on animals as part of...
Most scientists and governments say they agree that animal testing should cause as little suffering as possible, and that alternatives to animal testing need to be developed. The "three Rs", first described by Russell and Burch in 1959, are guiding principles for the use of animals in research...
Traditionally, experiments with e.g. pregnant rats have been used to assess the amount of a given chemical that is passed on to the rat's fetus. The new study from the National Food Institute shows promising results when using the alternative approach, as the computational models were able to...
Alternatives to animal testing and the identification of reliable methods that may decrease the need for animals are currently the subject of intense investigation worldwide. Alternative testing procedures are particularly important for synthetic and natural chemicals that exert their biological actions throug...
integrated testinginterspecies differencesThere is a very high rate of withdrawal of new drugs during or even after clinical trials, due to lack of efficacy or adverse side-effects not identified during expensive and time-consuming preclinical testing, much of it involving laboratory animals. For ...
Replacement methods represent the ultimate goal of the alternatives approach to basic biomedical research, testing and education. Refinement refers to those techniques and attitudes that alleviate or eliminate pain and distress experienced by the animals utilized in laboratory procedures. This may involve ...
Developing alternatives is undeniably important to improve the quality of science, but where animal testing of vanity products such as cosmetics is concerned, a lack of alternatives should never be allowed to stand in the way of the ethically right course of action, and in this case that would...
In conclusion, there will always be debate concerning the benefits and drawbacks of animal research. It may be preferable to test a product on animals before testing it on humans, yet this devalues an animal’s life. However, the ethics of life values are not black and white because more ...
In fact, while much of the publicity in the burgeoning field of biomarkers focuses on clinical applications such as companion diagnostics, the in vitro methods for preclinical testing are quite similar. So while technical and other challenges have served to limit sample sizes for biomarker studies,...