The efficacy of quinipristin/dalfopristin for the treatment of multiple-resistant enterococcal infection appears promising based on open-label, noncomparative clinical and bacteriologic outcome data. The rapid accumulation of more outcome data in an ongoing emergency use program for VRE infection should...
H. et al. Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection. Gut 68, 1791–1800. https://doi.org/10.1136/gutjnl-2018-317842 (2019). Article CAS Google Scholar Gloor, G. B., Macklaim, J. ...
angiogenesis, and treatment response. Taken together, these studies demonstrate the diagnostic and therapeutic value of AS and AS-related RBPs in GBM. The screening of specific RNA ASEs or RBPs to mitigate malignant
Ingham (1972) proposed the significant role of post-infectional antifungal compounds and phytoalexins in plant disease resistance, suggesting the possibility of developing their synthetic analogues for crop protection. This foresight points to the ongoing potential for natural products to inspire new, ...
The use of in vitro pharmacodynamic models of infection to optimize fluoroquinolone dosing regimens. Bristol Centre for Antimicrobial Research and Evaluation, North Bristol NHS Trust and University of Bristol, Department of Medical Microbiology, Southmead ... MacGowan,Rogers,Bowker - 《Journal of Antimic...
In order to determine the infection mice model for evaluating treatment or prophylaxis in rotavirus infection which is challenged by EDIM strain, one-week-old, two-week-old and three-week-old mice were infected with EDIM following by observing diarrhea and bodyweight changes, detecting immune res...
TT30 selectively inhibits CAP in cynomolgus monkeys and is bioavailable after subcutaneous injection. Using a unique combination of targeting and effector domains, TT30 controls cell surface CAP activation and has substantial potential utility for the treatment of human CAP-mediated diseases. 展开 ...
As infections are a significant cause of morbidity, mortality, and resource utilization after HCT, data from this study may enable transplantation physicians to better select the optimal donor source and to use more effective infection prevention and treatment strategies. Patients and Methods ...
Nevertheless, treatment of AZD5582 and the resulting activation of the alternative NF-κB pathway was insufficient to amplify Fascin on protein level (Figure 6B,D). On transcript level, however, little induction of Fascin was observed that was significant for one concentration of AZD5582 (Figure ...
L. et al. Antibiotic treatment for Clostridium difficile-associated diarrhea in adults. Cochrane Database Syst. Rev. 7 Sep 2011 (doi:10.1002/14651858.CD004610.pub4). Rea, M. C. et al. Effect of broad- and narrow-spectrum antimicrobials on Clostridium difficile and microbial diversity in a ...