Naturally occurring peptides with high membrane permeability often have ester bonds on their backbones. However, the impact of amide-to-ester substitutions on the membrane permeability of peptides has not been
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In contrast to these PDE families, splice variants of cGB-PDE have not been reported yet. In our previous studies, the amino-terminal portion of rat cGB-PDE was shown to be different from those of bovine and human cGB-PDEs, although two cGMP binding domains and one catalytic domain were ...
RBPs could be molecular orchestrators ofneuronal differentiation. RBPs known to regulate alternative splicing in the brain includepolypyrimidine tractbinding protein 2 (PTBP2). The roles of PTBP2 in the brain has been difficult to dissect. Neural stem cells...
Applications were performed in an Applied Biosystems PCR system for 40 cycles. Ten μL aliquots of the PCR products were size-separated by electrophoresis on a 2% agarose gel. Real-time quantitative PCR was performed by using SYBR Green Master mix and ROX reference dye, according to the ...
The MS transfer line temperature was set to 280°C. The acquisition mass range was 30 amu to 500 amu, and mass spectra were acquired in the scan mode at 3.33 scan/s. The Shimadzu ChemStation software was used to analyze the mass spectra and chromatograms. Monosaccharide composition was...
Similarity to an internal ribosome entry sites (IRES) motif was predicted by the UTRscan program for the end of AltT2 (nt170 – 262, mutation at position 188), but was not affected by the mutation, and was not found in the full EST BG719874-predicted 50UTR. Translation of the 556 bp...
The first World Health Organization (WHO) global report on antibiotic resistance published in 2014 specified that, "This serious threat is no longer a predic- tion for the future, it is happening right now in every region of the world and has the potential to affect anyone, of any age, ...
The main domain structures of OsCPK17, identified using InterProScan or estimated by sequence homology to other CDPKs, are depicted in Fig. 1. Further details discussed throughout the paper are also highlighted in the structure diagram (Fig. 1A) and the protein sequence (Fig. 1B). We ...
This appears in contrast to previous findings [19], but may be due to differences in cell composition and technical variation. Most of the 2.3. CompDaMraWblsewDeNreAlocMateetdhiynlianttieorngePnaicttreergniosnbse,tawndeefnewBelroiondinatnrdagSenalicivraegaitonDseafinndeedxoGnesn(oSmupipclReme...