Definition Alternative splicing refers to the post-transcriptional modification process in which coding regions (exons) of a primary transcript are joined in different combinations through the removal or retention of non-coding intervening sequences (introns) to produce distinct mature messenger RNA (mRNA...
Alternative splicing refers to the process of producing different mRNA splice isoforms from an mRNA precursor through different splicing modes, and the final protein products exhibit different or antagonistic functions and structural properties or cause different phenotypes. ...
来自 Springer 喜欢 0 阅读量: 2 摘要: Alternative RNA splicing refers to the synthesis of different RNA molecules from a single product by differential usage of splicing junctions, which are the sequences surrounding the exon﹊ntron... DOI: 10.1007/978-3-540-47648-1_212 年份: 2008 ...
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We found that alternative splicing of LSD1 transcript generates four full-length isoforms from combinatorial retention of two identified exons: the 4 aa exon E8a is internal to the amine oxidase domain, and its inclusion is restricted to the nervous system. Remarkably, the expression of LSD1 ...
Alternative splicing (AS) is a post-transcriptional regulation that leads to the complexity of the transcriptome. Despite the growing importance of AS in cancer research, the role of AS has not been systematically studied, especially in understanding can
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Myeloid cell leukemia-1 (MCL-1), which usually refers to the long isoform (MCL-1L) is frequently overexpressed in various types of cancer. However,pre-mRNA can also undergo alternative splicing through exon skipping to yield the short isoform, MCL-1S. Regarding its structure and function, MCL...
Alternative splicing (AS) has been regarded capable of altering selection pressure on protein subsequences. Particularly, the frequency of reading frame preservation (FRFP), as a measure of selection pressure, has been reported to be higher in alternatively spliced exons (ASEs) than in constitutively...
Alternative splicing (AS) is a pervasive molecular process generating multiple protein isoforms, from a single gene. It plays fundamental roles during development, differentiation and maintenance of tissue homeostasis, while aberrant AS is considered a h