The attention mechanism can be used to increase the difference between isoform pairs from the same gene bag in the context of interaction prediction [71] or to account for the fact that two or more proteoforms from the same gene can work together to accomplish the same function [73]. Semi...
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i(Supplementary Tables1,2) in MDCK wt vinculin was positioned proximal to the cadherin/catenin compartment (vinculin N-terminus atzcenter = 55.93 nm, compared to 58.61 nm for the C-terminus), where α-catenin assumes an open conformation, as previously demonstrated by α18 ...
To further elucidate the cellular function of mysterin, we searched for substrates and/or cofactors using liquid chromatography–tandem mass spectrometry (LC-MS/MS), ultimately identifying USP15. Here, we report the first example of isoform-specific bias in substrate preference of USP15. Biochemical...
Heterogeneous nuclear ribonucleoprotein M (HnRNPM) is a key splicing factor involved in various biological processes, including the epithelial‒mesenchymal transition and cancer development. Alternative splicing is widely involved in the process of spermatogenesis. However, the function of hnRNPM as a sp...
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With global phosphate rock resources declining for conventional fertilizers, there is growing interest in exploring alternative, more sustainable materials
As an initial test for the function of Nrxn1 S5, we used a molecular replacement strategy in cultured hippocampal neurons. We knocked down all Nrxns15 and rescued with a mixture of RNAi-resistant Nrxn1α and -1β with or without the 3-amino acid S5 splice insert. Nrxn knockdown reduced...
the MM2 domain interacts with the BTR complex to coordinate the stabilization of replication forks; and the MM3 domain has no known function. A key site at S1045 is phosphorylated upon genotoxic stress and is required for efficient ATR-CHK1 checkpoint activation38. The ERCC4 endonuclease domain ...
acids or mRNA isoforms with different 30-untranslated regions (tandem 30 UTRs) that may have an important role in regulating the function, stability, localization and translation efficiency of target RNA, as the 30 UTR serves as the major docking platform for RNA binding proteins and microRNAs7....