Over 95% of mammalian multi-exon protein-coding genes have more than a single isoform30,31; therefore, many studies have sought to identify RNA molecules generated by AS, and deduce their influence on cell proteomes32,33,34. However, knowledge on the impact of different splicing variants on ...
Figure 5. Alternative splicing (AS) events make a major contribution to transcript diversity in the cortex (A) An overview of the different types of AS considered in our analysis. (B) Alternative first (AF) exon use is the most prevalent AS event in both the human cortex and mouse cortex...
The latter category represents exon inclusion levels in treated HSALR mice that shift splicing further from WT levels as compared to untreated HSALR. Table 2. Therapeutic summary table organized by author, tissue, therapeutic and dosage, approach, time, and delivery method First authorTherapeutic ...
The SpE-protein gene spans 22 exons and the intron-exon structure (including exon phase) is highly conserved with that of the vertebrate loci (Fig. 1A; S1). As in vertebrates, the first exon of SpE-Can is noncoding; the start of translation is located in the second exon. We also ...
Specific exon inclusion events in the CDC14B, CD44, SETD5, ST7, and HP1BP3 pre-mRNAs mirrored the RNA-seq results in all cases (Figures 2C, 2D, and S3). Taken together, our results indicate that Matrin3 binding close to 3′ splice sites suppresses AS and that its loss results in...