Figure 5. Alternative splicing (AS) events make a major contribution to transcript diversity in the cortex (A) An overview of the different types of AS considered in our analysis. (B) Alternative first (AF) exon
Over 95% of mammalian multi-exon protein-coding genes have more than a single isoform30,31; therefore, many studies have sought to identify RNA molecules generated by AS, and deduce their influence on cell proteomes32,33,34. However, knowledge on the impact of different splicing variants on ...
The identification of alternative proteins is at present uncommonly performed due to both analytical and computational challenges, including the possible aforementioned frameshift, low abundance of alternative transcripts, and sequence properties near exon–exon junctions.8., 9., 10., 11. In part ...
The SpE-protein gene spans 22 exons and the intron-exon structure (including exon phase) is highly conserved with that of the vertebrate loci (Fig. 1A; S1). As in vertebrates, the first exon of SpE-Can is noncoding; the start of translation is located in the second exon. We also ...