Uric acidHyperuricemiaDiabetic nephropathyKidney diseaseType 1 diabetesType 2 diabetesPurpose of Review Multiple experimental and clinical studies have identified pathways by which uric acid may facilitate the development and progression of chronic kidney disease (CKD) in people with diabetes. However, it ...
of apoptoticβ-cell remnants, altered immune regulatory functions, and environmental factors such as viral infections determine the outcome. Autoreactivity might exist under physiologic conditions and when the integrity of the complex regulatory process is damaged the disease might develop. We summarized t...
Further analysis revealed a significant increase and decrease in the relative levels of 12 and 30 differential metabolites, respectively, in patients with MS as compared with healthy subjects (Figures 2B and S3). We observed that the relative levels of several amino acid metabolites, such as L-...
Altered platelet reactivity in peripheral vascular disease complicated with elevated plasma homocysteine levels. Elevated plasma concentrations of the sulphur-containing amino acid homocysteine (Hcy) is associated with increased risk of atherosclerosis and arterial th... R Riba,A Nicolaou,M Troxler,... ...
Altered Uric Acid Levels and Disease States Altered serum uric acid concentrations, both above and below normal levels, have been linked to a number of disease states. An abnormally high uric acid le... MK Kutzing,BL Firestein - 《Journal of Pharmacology & Experimental Therapeutics》 被引量: ...
the healthy controls, whereas the levels of 17 metabolites (lactate, alanine, N-acetyl glycine, glycerate, serine, pyroglutamic acid, 2,3,4-trihydroxybutyrate, glutamic acid, phenylalanine, glutamine, citric acid, tyrosine, palmitic acid, uric acid, linoleic acid, oleic acid, and stearic acid) ...
More than 60% of all cancer patients receive radiotherapy alone or in multimodal combinations of surgery, radiotherapy and chemotherapy during the course of their disease, resulting in favorable effects on local tumor regression, long-term survival, and even tumor cure [1–4]. However, treatment ...