In addition, 98 epigenomes were also annotated with an 18-state model that includes H3K27ac. We looked first at the epigenetic state of the DMRs in adult lung (epigenome E096). Compared to all potential regions, hypoDMRs were enriched in the enhancer states, ZNF/Rpts state, and ...
Lastly, since we observed an increased high fat state in mouse placenta of rapamycin-induced FGR in mice, we investigated the potential of maternal exercise as a moderator to promote fetal growth. The objective of our study was to elucidate the precise mechanism by which mTOR signaling may ...
Concerns about rapidly changing ecosystems in a warmer and more fire-prone future have catalyzed development of multiple frameworks conceptualizing resilience to fire (e.g., capacity to experience fire without shifting to an alternative state; cf. Walker et al. 2004). Fire-prone ecosystems that are...
Using elemental and isotopic fingerprinting in high- resolution sedimentary pore water samples from Site J100325, we reveal that the meteorically altered geothermal waters supplying thermal springs at surface locations in Patagonia have also infil- trated marine sediments on the Chilean Margin, ...
For DHX, exhaustively (>98%) deuter- ated A26–55 peptides were diluted to a concentration of 5 µM into a protonated solvent, which leaves them in the monomeric state27. Exchange of amide deuterons to protons was recorded over time at pH 5.0 and 20 °C. Gradual shifting of ...
The flankers (Hs) could be displayed either near the target T or in the intermediate position, and all the fillers occupied the locations left over. Both T and H could have one of four possible rotations (0–270 deg in steps of 90 deg) selected independently among them and randomly at ...
Using elemental and isotopic fingerprinting in high- resolution sedimentary pore water samples from Site J100325, we reveal that the meteorically altered geothermal waters supplying thermal springs at surface locations in Patagonia have also infil- trated marine sediments on the Chilean Margin, ...
response may be an acute adaptation during the early stage of trauma and that energy exhaustion may occur in the later stage of acute neuronal trauma, thus mimicking a chronic neurodegenerative state. Evidence related to glaucoma, a chronic optic nerve injury, also supports our suspicion. RGCs ...
If we assume that these margins are in a near steady-state then the CO2 output flux produced by the volcanic arc (through persistent and diffuse degassing) should match this input flux, unless other processes of CO2 loss or gain are in play. As noted in Aiuppa et al. (2019), current ...
6C). However, the strong binding of MeCP2 to unmethylated four-way junction DNA (20) supports the concept that DNA geometry at the nucleosome dyad favors MeCP2 binding regardless of the methylation state. Mutations in MeCP2 that cause RTT differ in their linker protection capacities. Although...