Using this model we show for the first time that bronchial ECM derived from COPD patients has an impact on gene expression in airway epithelial cells early during the differentiation process. The differential gene expression pattern indicates altered activity of upstream mediators involved in regeneration...
It is well known that oxidant-antioxidant imbalance plays a key role in the pathophysiology of chronic obstructive pulmonary disease (COPD).To examine the role of altered levels of oxidant-antioxidants in disease severity of COPD and correlate it with the degree of airflow obstruction.We assessed ...
(COPD). A chronic inflammation of the lungs. About this article Cite this article Schuller, H. Is cancer triggered by altered signalling of nicotinic acetylcholine receptors?.Nat Rev Cancer9, 195–205 (2009). https://doi.org/10.1038/nrc2590 ...
COPDoxidative stressreactive oxygen speciesantioxidantsBACKGROUND: It is well known that oxidant-antioxidant imbalance plays a key role in the pathophysiology of chronic obstructive pulmonary disease (COPD).Ahmad, A.Shameem, M.Husain, Q.The international journal of tuberculosis and lung disease: the ...
Adenosine, an endogenous purine nucleoside, has been strongly implicated in asthma pathophysiology and also has potent effects on the cardiovascular system. This work was undertaken to gain a better understanding of the relationship between asthma and its cardiovascular effects, and more specifically the...