Following ligation by B cell-activating factor (BAFF), BAFFR mainly induces the alternative nuclear factor-κB pathway to promote pro-survival signals. Mice that are deficient in BAFF or BAFFR have a block in B cell development at the transitional type 1 stage. Systemic lupus erythematosus (SLE...
This is a change of pace for author Brent A Harris - and a good one at that. Better known for his alternative histories, Harris has this time created a thriller that's a chiller, about a young woman who becomes the target of an obsessive artificial intelligence. Christine is adrift, her...
Following ligation by B cell-activating factor (BAFF), BAFFR mainly induces the alternative nuclear factor-κB pathway to promote pro-survival signals. Mice that are deficient in BAFF or BAFFR have a block in B cell development at the transitional type 1 stage. Systemic lupus erythematosus (SLE...
Our results also offer further insight into alternative strat- egies for pest management in chili pepper, one of the top ten vegetable crops in the world (FAOSTAT 2020). The use of mixed varieties in agriculture has been shown to reduce pest pressure by slowing the spread of insects via ...
Addressing alternative hypotheses for cytokine-skewing in the TCR transgenics The TCRαβ transgenic lines make more IL-2 than littermate controls, indicating T cell survival potential (Figure 5A). The high IL-2 response in the TCRαβ transgenic line, taken together with the high IL-9 and ...
An alternative way of showing this between-sub- groups efficacy difference is presented in Figure 8. Here we have calculated the increase in [35S]-GTPgS bound to Gaq/11 proteins (as fmol per mg membrane protein) stimulated by a maximally effective oxotremorine-M concentration and compared ...
δ = 0. The two-tailed alternative hypothesis (H1) states that the two groups differ from each other. The default prior option provided by JASP was used to assess the likelihood of the alternative hypothesis given the data (BF10) compared to the null hypothesis. The Bayes factor may in...
21 Recently, we developed a successful gene therapy protocol, based on autologous transplantation of retrovirally transduced hematopoietic stem/progenitor cells (HSCs) combined with low-intensity conditioning, as an alternative therapeutic option.22 Results of this clinical trial showed the long-term ...
Alternative splicing of the human TCF7L2 gene exhibits both general and tissue-specific features, the latter including the pancreatic islets where transcripts containing exon4 are at twice the level observed in other tissues. The alternative exon4 is one of several alternative exons in TCF7L2; ...
In addition, a variant AR messenger RNA, probabily derived from alternative splicing, was observed. We found that AR is expressed both in healthy and in neoplastic colon mucosa, either as mRNA or as protein. Neoplastic colon tissue shows a characteristic loss of expression of the AR〣 isoform...