关于是否应调低丙氨酸转氨酶(alanine aminotransferase,ALT)参考上限(upper limit of normal,ULN)的争论已持续了近 20 年,临床医生提出应降低 ALT 参考上限主要出于两方面的考量 :一是对于慢性乙型肝炎启动抗病毒治疗的时机,调低起始治疗的 A...
《慢性乙型肝炎防治指南》推荐意见10提出 :对于血清HBV DNA阳性,ALT持续异常,即超过正常值上限(upper limit of normal, ULN),且排除其他原因所致者,建议抗病毒治疗。ALT水平一直是CHB指南启动抗病毒治疗的焦点。目前,国外的大多数指南将ALT...
Summary Introduction Given the global rise in obesity‐related metabolic diseases, the upper limit of normal (ULN) alanine aminotransferase (ALT) in individuals with and without metabolic diseases may have changed. We performed a meta‐analysis combined with bootstrap modelling to estimate the ALT ...
The current alanine aminotransferase (ALT) upper limit of normal was defined using selected healthy Caucasian blood donors. Given the global rise in obesity and different body habitus in Asians, we aimed to perform a systematic review and meta-analysis combined with bootstrap modeling and individual...
ULN:Upper Limit Of Normal, 正常上限 INR:International normalized ratio, 国际标准化比率 TB:Total bilirubin, 总胆红素 BIL:Bilirubin, 胆红素 Child-Pugh分级:A级为5～6分;B级为7～9分;C级为10～15分。 Child-Pugh肝脏疾病严重程度记分与分级 当患者出现肝功能损伤,除了调整药物剂量或停药外,仍需要配合多种...
(hepatitis B virus, HBV) DNA≥105拷贝/mL(HBeAg阳性)或104拷贝/mL(HBeAg阴性), ALT持续升高≥2×正常值上限(upper limit of normal, ULN). 依Keeffe等的上述新"标准"而论, 国内临床医师会不可避免的产生困惑, 即CHB患者如果ALT水平恰好处于男≥60 IU/L和女≥38 IU/L, 是否需要给予规范的核苷(酸)类似...
There is also a wide gap between the upper limit of normal and dangerously high results. Mild elevations are generally considered to be two to three times the ULN. With some liver diseases, the level can be more than 50 times the ULN. Levels this high are described as deranged.5 ...
It has recently been proposed that the true upper normal limit of serum alanine aminotransferase (ALT) is much lower than that listed by the manufacturers of commercially available assays. The normal ranges for laboratory parameters such as serum ALT are often derived from the assessment of only ...
Key words: Hepatitis B, chronic; Low alanine aminotransferase; Liver pathology; Diagnosis ALT 2 N-Terminal Procollagen 病理学肝组织活检术仍是诊断 < 倍正常 型前胶原氨基端肽( Ⅲ 值上限(upper limit of normal value ,ULN )慢性乙 Propeptide P P ,Ⅲ )、天门冬氨酸氨基转移酶 型肝炎患者肝纤维化的...
Objective To investigate the indexes selection in non-invasive diagnostic model for liver fibrosis in chronic hepatitis B patients with ALT below 2 times of the upper limit of normal (ULN).Methods Total of 249 chronic hepatitis B patients with ALT< 2 × ULN in the Third P...