One consequence of fALS associated mutations in SOD1 [Swiss-Prot: P00441] that seems to be shared by all mutants is that the mutant SOD1 is far more prone to adopt aberrant conformations that result in its aggregation [1]. This common property is easily assessed in cultured cell models in...
分泌所需的信号肽(氨基酸 1-27)在运输过程中被分解(Swiss-Prot P35858 版本 82)。因此,成熟的红色蛋白质由 578 个氨基酸组成,富含亮氨酸的序列是 ALS 蛋白质的特征。除了这 20 个富含亮氨酸的序列部分之外,还有许多 N 连接糖链的糖基化位点。 Miller BS 等人在他们的研究中能够表明,IGF-1、IGF-II、ALS ...
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Using Swiss-Model [67], the new structures were generated, based on proposed PDB template structures with high coverage and identity percent with the primary amino acid sequence. The FASTA amino acid sequences used, the structures used as templates, and the degree of identity are presented in ...
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Similarity searches for peptide annotation were also conducted against TAIR10, Brachypodium distachyon proteome, Swiss-Prot and TrEMBL using the BLASTp algorithm with an E-value < 10−5. Additional Pfam domain assignation was performed using the Pfam-A 27.0 database and the hmmsearch program...