Expected incidence was estimated from the age distribution of the Gulf War veteran population, weighted by age-specific death rates of the US population. Secular changes in nationwide ALS rates were assessed using calculations of the age-specific US population death rates from vital statistics data ...
Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset neurodegenerative disease characterized by the progressive loss of upper and lower motor neurons (MNs) resulting in muscle weakness and atrophy [1,2]. The majority of ALS patients starts to develop symptoms between 51–66 years of age an...
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Standardized mortality ratios (SMRs) were calculated based on the ratio of the observed to the expected number of deaths within a year. The death calculations were based on the age and sex-specific mortality statistics of Oklahoma State from 2010 to 2020. SMRs and crude mortality rates (per ...
e Violin plots showing the partial residuals of gene fusions in CTRL (blue, n = 90) and ALS (red, n = 306) in paired-end sequenced iPSMNs, controlling for age, read depth and dataset. Statistics are from the generalised linear model Wald test using a Poisson distribution. f ...
response to treatments. Issues in working with mouse models, such as which genetic mutation to use, on which genetic background, at which stage of lifespan/disease development, are well known, and need to be carefully addressed, along with robust statistics on cohort sizes and sex differences....
Microglia play crucial roles in maintaining neuronal homeostasis but have been implicated in contributing to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However, the role of microglia in ALS/FTD remains incompletely unders
(SCENIC) defined by the top 10 betweenness centrality score (Cytohubba in Cytoscape) for interacting TFs (nodes) and grouped into functional domains based on gene/protein function (https://www.uniprot.org). Node size illustrates centrality score. See Supplementary Table3for detailed statistics. ...
Statistics Demographic data were analysed using Student’s t test (age) and the χ2 test (sex and race). Student’s t test was used to compare log10-transformed protein measurement levels between two groups. The Storey method was used for multiple testing correction. Two-way ANOVA followed ...
Statistics and reproducibility For all experiments, n ≥ 3 or more biological replicates for each condition examined except immunofluorescence characterization experiments in Figures 4, S1, and S2 (n = 2). Fold changes, SEM, SD, and statistical analyses were performed using GraphPad Prism version 9....