ALS patients of other races were more likely than White ALS patients to be diagnosed at a younger age and to experience twitching. The mean interval between the first sign of weakness and an ALS diagnosis for Black patients was almost 24months, statistically greater than that of White ( p =...
A 6-month double-blind study of bovine brain gangliosides was carried out in 40 patients with ALS. Thirty-two patients completed the study; 18 were treated with gangliosides and 14 with placebo. Using 10 different objective tests of musc... H Harrington,M Hallett,HR Tyler - 《Neurology》 ...
A variety of outcome measures are used in clinical practice and in research to assess patients with amyotrophic lateral sclerosis (ALS). However, there may be discordance between traditional outcome measures such as strength and physical function, and patient-perceived measures of well-being. One suc...
Amyotrophic Lateral Sclerosis, also known as Lou Gehrig’s Disease or ALS, is a progressive, degenerative disease of the nerves that control voluntary movement. This disease results in total immobility and eventually death. Patients with ALS often notice early symptoms like abnormal clumsiness, droppin...
Prognostic value of BRAF/MIR-17 signature and B-Raf protein expression in patients with colorectal cancer: A pilot study. The adenoviral early region 1A (E1A) protein mediates sensitization to different stimulus-induced apoptosis, such as tumor necrosis factor alpha, UV and ga... AT Ibrahiem,MS...
Wiesenfarth M, Dorst J, Brenner D, Elmas Z, Parlak Ö, Uzelac Z, et al. Effects of tofersen treatment in patients with SOD1-ALS in a "real-world" setting - a 12-month multicenter cohort study from the German...
The findings that amyotrophic lateral sclerosis (ALS) patients almost universally display pathological mislocalization of the RNA-binding protein TDP-43 and that mutations in its gene cause familial ALS have nominated altered RNA metabolism as a disease mechanism. However, the RNAs regulated by TDP-43...
To this end, we performed whole-exome sequencing (WES) in a Chinese cohort (670 sporadic ALS patients and 1910 controls) and identified 8 rare variants in CLCC1 in the patients, including 6 nonsynonymous and 2 stop-gain mutations (Fig. 5a; Supplementary information, Fig. S15 and Table S1...
Measurement of ALS in human serum may be useful in diagnosing the growth hormone status of patients with growth disorders. The IGF binding protein complex formed by admixing ALS, IGF and the acid stable protein BP-53, where each component is preferably in biologically pure form, may be ...
site of disease onset predominantly a limb rather than bulbar and a mean age of disease onset of approximately 57 years. The mean delay in clinical diagnosis forALS patientsincluded in the study was 14.8 months. A higher percentage of patients with rapid progression had bulbar-onset disease...