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The noncoding genome is substantially larger than the protein-coding genome but has been largely unexplored by genetic association studies. Here, we performed region-based rare variant association analysis of >25,000 variants in untranslated regions o
lead to higher DPR expression and exacerbate the disease. Mutation inZNF598(R69C) has been linked to ALS from large-scale genome-wide association study93. The dysregulation in RQC pathways will be a risk factor not only for increasing DPR expression but also for generating global cellular stres...