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The exact cause of the disease is unknown, but up to 20% of familial ALS cases and as many as 2% of sporadic cases are associated with mutations in the gene SOD1, which codes for an enzyme called superoxide dismutase (SOD1).The SOD1 enzyme neutralizes free radicals, which are by...
Despite recent technical improvements in organoid culture methods5,6,7, there are a number of challenges remaining for neurodegenerative disease modeling. Brain organoids have been grown from cells derived from patients with Parkinson’s disease and from patients with Alzheimer’s disease for 30 or 8...
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Ethical approval for the study was obtained from the NHS research ethics committee (RNEC) and in accordance with the Human Tissue Authority’s codes of practice and standards under license number 12198. We have conformed with all relevant ethical regulations related to informed consent and ...
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