TheALS-600 provides continuous frequency coverage from 1.5 through 22 MHz with notuning adjustments. Broad band 5 pole low pass filters provide output harmonicsuppression in excess of all FCC requirements. Export modifications are available toextend operation up to 30 MHz with a copy of a valid ...
Results Diverse cell populations segregate in hiPSC-derived ALI-COs First, we examined whether C9 ALI-COs develop similar cell-type diversity and cytoarchitecture to their healthy control patient-derived counterparts to assess their relevance to disease-affected phenotypes. The following ALI-COs were pr...
Nup107, Nup153, Nup205, and Nup214 have also been identified as substrates of thioredoxin1, a redox protein essential for the removal of specific disulfide bonds and other cysteine post-translational modifications (Wu et al., 2014), suggesting that the NPC is subject to increased and age-...
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Its activity is regulated by multiple posttranslational modifications including phosphorylation. Phosphorylation of HDAC6 can increase its enzymatic activity or protein stability [60,61,62, 83, 84]. MAP4Ks may also regulate HDAC6 in a similar fashion since their inhibition by Hit3 or shRNA-...
Nuclear import of TDP-43 is driven the importin-α/β1 complex, where the NLS of TDP-43 is recognized and bound by several importin-α family members [212]. Importin-α1 preferentially associates with the minor site of the NLS, and post-translational modifications in proximity of that site...
8. Li H, Li J, Chen J, Yan L, Xia L: Precise Modifications of Both Exogenous and Endogenous Genes in Rice by Prime Editing. Molecular Plant 2020. 期刊介绍 Genome Biologycovers all areas of biology and biomedicine studied from a genomic and post-genomic perspective. Content includes research...
The most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) is an intronic G4C2 repeat expansion in C9orf72. The repeats undergo bidirectional transcription to produce sense and antisense repeat RNA species, whi
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Such accumulating evidence allows us to speculate that, under normal conditions, ALS2 acts as follows: Rac1 activation induces the conformational changes in the RLD by certain modifications on some residues, which in turn unlocked the RLD-mediated inhibitory switch; therefore, ALS2 can be recruited...