英文名称 ALPK1-IN-2 生化机理 ALPK1-IN-2 (化合物 T001)是一种强效的 ALPK1(α-激酶 1)抑制剂,其 IC 50 为 95 nM。ALPK1-IN-2 还能抑制 NF-κB,其 IC 50 为 1.31 μM。 储存温度 避光,-80℃储存 运输条件 超低温冰袋运输 产品介绍 ALPK1-IN-2 (compound T001) is a potent ALPK1 ...
化合物 ALPK1-IN-2 CAS号: 2765633-68-7 英文名: Benzamide, 4-(3,6-diazabicyclo[3.1.1]hept-3-yl)-2,6-difluoro-N-(4-methoxy-2-benzothiazolyl)- 英文别名: ALPK1-IN-2;Benzamide, 4-(3,6-diazabicyclo[3.1.1]hept-3-yl)-2,6-difluoro-N-(4-methoxy-2-benzothiazolyl)- ...
First-in-class原创新药DF-003是一种口服、强效、高选择性ALPK1激酶抑制剂。 ALPK1与心脏和肾脏疾病有关,而高活突变ALPK1是导致失明的罕见遗传病ROSAH的驱动因素。因此,DF-003有望治疗全球数亿患有心脏病和慢性肾脏疾病的患者,并为...
The in vitro protein levels of ALPK1 and URAT1 in ALPK1 small interfering RNA-transfected human kidney-2 cells with MSU crystal stimulation were examined. ALPK1, which is a single nucleotide polymorphism (SNP) of rs11726117 (M861T; T), reduced the risk of gout via the SLC22A12 gene SNPs...
Objectives To analyze the expression of urate transporters ABCG2, SLC22A12 and inflammation molecules ALPK1 and IL-1尾 in peripheral blood leukocytes from gout patients and to compare them with their metabolic profile and with the gene expression of people without gout and without hyperuricemia. ...
It was found that the expression of ABCG2 was higher in the patients and that the expression of OCT3 was higher in overweight people, regardless of whether they had gout or not compared with normal weigh people. The expression of ALPK1 was higher among patients and controls while the ...
AB0861Expression control by methylation of the TLR1, TLR2, TLR4, IL1B, ALPK1 SLC2A9 and SLC22A12 genes in monocytes of patients with goutBackgroundThe gout is an inflammatory multifactorial disorder where the diet, age, sex, absorption regulation of uric acid in kidney and genetic, ...
(b) determine whether the metabolic profile of gout patients can influence the gene expression profile and the expression of urate transporters, ABCG2 and SLC22A12, and inflammation molecules, ALPK1 and IL-1尾, in peripheral blood leukocytes from gout patients; (c) compare them with their ...