Alphaviruses are a genus of enveloped, positive-sense, single-stranded RNA viruses belonging to theTogaviridaefamily (Kuhn2007; Strauss and Strauss1994). Alphavirus virions are approximately 70 nm in size and consist of capsid proteins surrounding a single RNA genome and two transmembrane glycoprotein...
Structure and replication of the alphavirus genome. In: Schlesinger S, Schlesinger M J. ed. The Togaviridae and Flaviviridae. Plenum publishing Corp. 1986; 35–90.Strauss, E.G., and J. H. Strauss, 1986. Structure and replication of the alphavirus genome, Plenum Press, New York....
The Genome of GETV is 11,598 nt long. The strains of GETV, circulating in different geographical regions of northeastern and southeastern Asia, have a high level of similarity.8–11 A pairwise comparison of complete genome sequences revealed that isolates from Malaysia, South Korea, China, Mo...
We report here the complete nucleotide sequence of the genomic RNA of the alphavirus, O'nyong-nyong virus. The RNA is 11,835 nucleotides in length and the organization of the genome is typical of alphaviruses. Phylogenetic trees were constructed from the protein sequences of O'nyong-nyong ...
Table 1. Percent homology in nucleotide and amino acid sequences between E1 and challenge viruses. A. WEEV McM E1. B. VEEV Trinidad donkey E1. Challenge virus strains are WEEV McM, EEEV FL-93, and VEEV 3908. RegionWEEVEEEVVEEV A E2(aa) 100 44.75 42.18 E2(nt) 100 49.21 48.01 E1(...
1e. Three motifs are conserved in the amino acid sequences of alphaviruses and similar viruses such hepatitis E virus, rubella virus and more26,27: (i) the catalytic histidine (H37) responsible for the cap transfer; (ii) the DXG motif (in which X stands for any residue) (63DIG65 in...
Furthermore, the genome sequences of the identified miRNAs were analysed to reveal putativecis-regulatory elements, and, finally, their putative target genes were predicted. Twenty differentially expressed miRNAs (DE miRNAs) were identified. The expression of the majority of these increased post ...
Article: Sequence coding for the alphavirus nonstructural proteins is interrupted by an opal termination codon
Phylogenetic nucleotide conservation plots for selected alphavirus within-species full-genome sequence alignments. The nucleotide conservation in a 51-nt sliding window is expressed as ap-value plot, giving the probability that the conservation in the window would be as great or greater than that obse...
Therefore, it is plausible that the T = 3 virion could contain a complete genome with Vm = 3.1 Å3/Da. Alternatively, T = 3 particles could package a smaller RNA, such as the 26S subgenomic RNA of about 4.2kb, at even lower pressure. 4. Discussion The stability of T = 3 virions...