11. 21年10月4日 Alphafold-Multimer发布 DeepMind发布AlphaFold-Multimer https://www.biorxiv.org/co...
最近DeepMind开源了AlphaFold2代码，并且将AlphaFold2的paper刊登在nature上。出于好奇看了一下AlphaFold2的...
While in the predicted CEP164-TTBK2 “fused” complex, the Arg1076 alternative conformation can still support its role in stabilizing the complex, the conformation of this residue in the AlphaFold-Multimer model does not provide any clues to its possible function. We tested the importance of ...
G.A. wrote and optimized the OpenFold codebase, generated data, trained the model, performed experiments and maintained the GitHub repository. C.F. wrote and tested code for the OpenFold implementation of AlphaFold-Multimer. S.K. and W.G. wrote data preprocessing code. G.A., N.B. and...
As noted in the AlphaFold-Multimer paper, the AlphaFold/OpenFold template stack is a major memory bottleneck for inference on long sequences. OpenFold supports two mutually exclusive inference modes to address this issue. One,average_templatesin thetemplatesection of the config, is similar to the...
Any publication that discloses findings arising from using this source code or the model parameters shouldcitetheAlphaFold paperand, if applicable, theAlphaFold-Multimer paper. Please also refer to theSupplementary Informationfor a detailed description of the method. ...
the prediction of PHF14-HMG20A complex models. Ivanov et al.141also applied AlphaFold-multimer to predict the homodimers structure of CYP102A1. Recently, Bryant et al.142applied AF2 to predict heterodimeric protein complexes. In this work, they explored the docking effect by using the AF2 ...
G.A. wrote and optimized the OpenFold codebase, generated data, trained the model, performed experiments and maintained the GitHub repository. C.F. wrote and tested code for the OpenFold implementation of AlphaFold-Multimer. S.K. and W.G. wrote data preprocessing code. G.A., N.B. and...
Any publication that discloses findings arising from using this source code or the model parameters should cite the AlphaFold paper and, if applicable, the AlphaFold-Multimer paper.Please also refer to the Supplementary Information for a detailed description of the method....
This paper presents an innovative approach for predicting the relative populations of protein conformations using AlphaFold 2, an AI-powered method that has revolutionized biology by enabling the accurate prediction of protein structures. While AlphaFold