We could detect reproducibly, the presence of phosphorylation of human α-Syn at serine 129 position (human-specific α-Syn antibody for transgenic expression) which increased with ageing (Fig. 4b). Presence of synucleinopathy was investigated using trypsin/Proteinase K digestion to identify the ...
Antibodies against HNF-4α, PKM1, Cyclin A, Cyclin B1 and α/β-Tubulin were purchased from Cell Signaling Technology (Beverly, MA, USA) at 1:1000 dilution. Antibody against β-actin (1:2000 dilution) was the product of Santa Cruz Biotechnology, Dallas, TX, USA. AFP (1:1,000 ...
In this work, an EGFR-targeting monoclonal antibody (rituximab) was labeled with Pb-212 in a solution that also contained Ra-224. While the monoclonal antibody specifically targets (cancer) cells that overexpress EGFR, the additional bone-seeking properties of Ra-224 are able to simultaneously ...
The cytoplasmic and nuclear fractions were isolated from five distinct cell lines and visualised by Western blotting with antibodies against Nrf2, HO-1, and α-tubulin and histone3. Statistically significant increases ($) or decreases (*) were indicated by p≤ 0.01 (n≥ 3, or =3 × 3). ...
MET and the TAM kinases (TYRO3, AXL and MER); and XB002, a next-generation tissue factor (TF)-targeting ADC, administered via intravenous infusion and composed of a human monoclonal antibody (mAb) against TF that is conjugated to an auristatin-based microtubulin inhibitor (MTI) payload. It...