α-Thalassemia (α-thal) is a hereditary autosomal recessive anemia caused by deletions or mutations within the α-globin gene cluster consisting of two almost identical alpha 1 (α1) and alpha 2 (α2) globin genes on each copy of chromosome 16. ...
Fucharoen S., Winichagoon P., Pootrakul P., Piankijagum A. & Wasi P. (1987) Differences between two types of Hb H disease, alpha- thalassemia 1/alpha-thalassemia 2 and alpha- thalassemia 1/Hb constant spring. Birth Defects Original Article Series 23, 309-315....
first and last alpha Synonyms for alpha Collins WordNet phrasethe alpha and omega Synonyms first and last be-all and end-all Collins Thesaurus of the English Language – Complete and Unabridged 2nd Edition. 2002 © HarperCollins Publishers 1995, 2002 ...
METHODS: Single-tube multiplex real-time PCR with SYBR Green1 and high-resolution melting (HRM) analysis were used for the identification of alpha-thalassemia-1 Southeast Asian (SEA) and Thai type deletions and beta-thalassemia 3.5-kb gene deletion. The results were compared with those obtained ...
Alpha-globin genes were analyzed by the direct method of DNA mapping using alpha- and zeta-globin specific probes in a Thai family in which the proposita was an unusually mild beta zero-thalassemia homozygote. alpha zero-Thalassemia was found to be segregating in the family, inherited from the...
The alpha2 gene transcription amounts are two to three times more than alpha 1 gene transcription in alpha gene cluster. The Frequency and Importance of Common [alpha]-globin Gene Deletions Among [beta]-Thalassemia Carriers in an Iranian Population Under the agreement announced in August 2011, A...
Alpha-thalassemia/mental-retardation-syndrome-X-linked (ATRX) alterations are frequent in adult-type diffuse gliomas. They occur in astrocytic tumors carrying IDH1/2 and TP53 mutations but are mutually exclusive with 1p/19q codeletions. They are usually detected by a loss of expressio...
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Background: The combination of an x-linked hematologic disorder with a heterozygous alpha-thalassemia-1 Southeast Asian (SEA) type deletion might lead to severe anemia in male infants. This study is to develop a simple and cost-effective single tube multiplex real-time PCR for the diagnosis of...
Characterization of a New α-Thalassemia-1 Deletion in a Spanish Family A new type of α-thalassemia-1 was characterized in one Spanish patient with Hb H disease and in her mother. The restriction map of this deletion suggests ... J.,M.,Gonzalez-Redondo,... - 《Hemoglobin》 被引量: 64...