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KarlMuffly, inxPharm: The Comprehensive Pharmacology Reference, 2007 Microtubulesare the largest of the major components (24 nm), and are formed from tubulinheterodimerscomposed of alpha andbeta tubulin. The heterodimers form protofilaments with an alpha unit at the negative (-) and a beta unit ...
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Stan K. Bardal BSc (Pharm), MBA, PhD, ... Douglas S. Martin PhD Explore book FYI ▪ TNF-α was initially called cachexin and was described in 1975 for its ability to lyse tumors in animal models (giving rise to the name tumor necrosis factor). ▪ Cachectic is a term used to ...
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However, the molecular details underlying these processes, which have important implications for the selectivity of the peptides' membranolytic action, are only just starting to be understood. One important class of membrane-interacting AMPs assumes an amphipathic, α-helical conformation that permits ...