ALPHA-MANGOSTIN INHIBITS CD4+ T CELL AND MAST CELL ACTIVATION VIA THE Ca2+ RELEASE ACTIVATED Ca2+ CHANNEL This study investigated whether -mangostin reduces CRAC currents (I SB CRAC sb ), and thus, inhibits mast cell degranulation and T cell activation. T cell proliferation induced by co-...
The TRPV3 calcium ion channel is vital for maintaining skin health and has been associated with various skin-related disorders. Since TRPV3 is involved in the development of skin inflammation, inhibiting TRPV3 could be a potential treatment strategy. Alpha-mangostin isolated from Garcinia mangostana ...