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BackgroundSteroid 5-alpha-reductase deficiency (5-ARD) is one of the causes of male pseudohermaphroditism. It is a rare autosomal recessive disorder due to the deficiency of an enzyme responsible for the conversion of testosterone to dihydrotestosterone (DHT). This results in failure of full ...
This is probably related to the different hormonal settings, given that AAT expression is increased in male PiZ mice and testosterone treatment of female PiZ mice increased Z-AAT expression to a level comparable with that in males [27]. However, while PiZZ subjects have a higher incidence of ...
Nevertheless, the connection is a particularly intriguing concept given that most cases of prostate cancer arise in the sixth decade of life, a time when testosterone levels are decreasing and oestrogens are increasing in men. Mouse models suggest that antagonism of ERα may diminish prostate ...
Summary Background and objective 5-Alpha reductase type 2 deficiency (5-ARD) is a rare disorder of sex development. The lack of 5-alpha reductase, an enzyme that converts testosterone into dihydrotestosterone, results in external genitalia that may appear female, or predominantly male, albeit ...