Galactose-alpha-1,3-galactose (α-gal) is a sugar structure found in glycoproteins and glycolipids from all mammals except primates, including humans. Allergy to red meat (beef, pork, lamb) usually involves delayed-type reactions (3–6 h postingestion), and this should raise suspicion...
[12]. The structure was then synthesized and optimized bymedicinal chemistryusing the tumor metastases assay[13,14]. αGalCer has α-linkedgalactose, a phytosphingoidbasechain with 18 carbons, and an acyl chain containing 26 carbons. αGalCer has not yet proven highly successful in human cancer ...
Galactose-alpha1,3-galactose (alpha1,3Gal) is the major xenoantigen causing hyperacute rejection in pig-to-human xenotransplantation. Disruption of the gen... Y Dai,TD Vaught,J Boone,... - 《Nature Biotechnology》 被引量: 1647发表: 2002年 Prostate-specific antigen in serum occurs predominant...
Hemagglutination inhibition studies with oligosaccharides of known structure also showed that the antibody binds specifically to glycoconjugates with an alpha 1---3 terminal galactose residue. Anti-Gal did not bind to a human B-active glycolipid, indicating that fucose-linked alpha 1---2 to the pen...
Structure and dynamics of an undecamer DNA duplex containing a single α-anomeric deoxyadenosine residue placed in opposition to a thymidine unit have been studied using simulation of molecular dynamics in aqueous solution. Despite several noticeable deviations from the B-DNA duplex structure caused by...
Alpha Helix Structure | Beta Sheet, Hydrogen bonds & Proteins from Chapter 2/ Lesson 14 48K Learn about the alpha helix. Discover the alpha helix structure and beta sheet hydrogen bonds, and examine alpha helix proteins and amino acids. ...
epitope in the latter species appears to result from the suppression of gene expression for the enzyme UDP-galactose:nLc4Cer alpha 1-3-galactosyltransferase (alpha 1-3GalT) (Joziasse, D. H., Shaper, J. H., Van den Eijnden, D. H., Van Tunen, A. J., and Shaper, N. L. (1989)...
The wbsJ gene from Escherichia coli O128:B12 encodes an al,2-fucosyltransferase responsible for adding a fucose onto the galactose residue of the 0-antigen repeating unit via an α1,2 linkage. The wbsJ gene was overexpressed in E. coli BL21 (DE3) as a fusion protein with glutathione S-tra...
It has been shown that after the removal of neuraminic acid, the most labile grouping in both glycoproteins is that involving galactose. Mannose, glucosamine, and galactosamine are the other components of the pentasaccharide which constitute the carbohydrate portion of both tumoral and normal ...
Uptake of 100 g of glucose, galactose, or both via this transporter thus transfers 25 g of sodium ions and 2.1 l of water from the lumen into and across the intestinal mucosa. A regulatory protein, RSC1A1, inhibits SGLT1 activity. The facilitative glucose transporter 2 (GLUT2, SLC5A2) ...